3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Organ Printing: Tissue Spheroids as Building Blocks
Vladimir Mironov,Jing Zhang,Carmine Gentile,K Brakke,Thomas C. Trusk,Karoly Jakab,Gabor Forgacs,Vladimirs Kasjanovs,Richard P. Visconti,Roger R. Markwald +9 more
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
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Nanomaterial-Enabled Wearable Sensors for Healthcare.
TL;DR: Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review.
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3D bioprinting of tissues and organs for regenerative medicine.
TL;DR: The current status and contemporary issues of 3D bioprinting pertaining to the eleven organ systems of the human body including skeletal, muscular, nervous, lymphatic, endocrine, reproductive, integumentary, respiratory, digestive, urinary, and circulatory systems were critically reviewed.
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3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
TL;DR: This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015.
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Recent Advances in Biomaterials for 3D Printing and Tissue Engineering
TL;DR: Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors.
References
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Journal ArticleDOI
3-dimensional bioprinting for tissue engineering applications
TL;DR: This review will introduce the principles and the current state of the 3D bioprinting methods, and focus on some of studies that are being current application for biomedical and tissue engineering fields using printed 3D scaffolds.
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Bio-ink for on-demand printing of living cells
Cameron J. Ferris,Kerry J. Gilmore,Stephen Beirne,Don McCallum,Gordon G. Wallace,Marc in het Panhuis +5 more
TL;DR: It is shown that a bio-ink based on a novel microgel suspension in a surfactant-containing tissue culture medium can be used to reproducibly print several different cell types, from two different commercially available drop-on-demand printing systems, over long printing periods.
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Three-Dimensional Printing of Tissue/Organ Analogues Containing Living Cells
TL;DR: 3D tissue/organ printing techniques and biomaterials that have been developed and widely used thus far are introduced and a variety of applications in an attempt to repair or replace the damaged or defective tissue/ organ are reviewed.
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Biofabrication and testing of a fully cellular nerve graft
TL;DR: A novel approach to biofabricate fully biological grafts composed exclusively of cells and cell secreted material is reported on, providing evidence that bioprinting is a promising approach to nerve graft fabrication and as a consequence to nerve regeneration.
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Three-dimensional printed PCL-hydroxyapatite scaffolds filled with CNTs for bone cell growth stimulation.
Elsa M. Gonçalves,Filipe J. Oliveira,Rui F. Silva,M.A. Neto,M. Helena Fernandes,M. Amaral,María Vallet-Regí,Mercedes Vila,Mercedes Vila +8 more
TL;DR: The composites show typical hydroxyapatite bioactivity, good cell adhesion and spreading at the scaffolds surface, indicating that the produced 3D, three-phase, scaffolds are promising materials in the field of bone regenerative medicine.