3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Journal ArticleDOI
Recent advances in 3D printing: vascular network for tissue and organ regeneration.
Sung Yun Hann,Haitao Cui,Timothy Esworthy,Shida Miao,Xuan Zhou,Se-Jun Lee,John P. Fisher,Lijie Grace Zhang +7 more
TL;DR: Materials and strategies for 3D printed vascular networks as well as specific applications for certain vascularized tissue and organ regeneration are discussed and the current limitations of vascular tissue engineering are addressed.
Journal ArticleDOI
Tunable Biomimetic Hydrogels from Silk Fibroin and Nanocellulose
Pramod Dorishetty,Rajkamal Balu,Sandya Athukoralalage,Tamar L. Greaves,Jitendra P. Mata,Liliana de Campo,Nabanita Saha,Andrew C.W. Zannettino,Naba K. Dutta,Naba K. Dutta,Namita Roy Choudhury,Namita Roy Choudhury +11 more
TL;DR: Biomimetic hydrogels offer a new platform for hierarchical structure-controlled, tough, biocompatible, mechanically tunable, and printable gels for regenerative medicine.
Journal ArticleDOI
Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review
TL;DR: An overview of photo curing-based bioprinting technologies is provided, and a visible light crosslinkable bioink is described, including its crosslinking mechanisms, types of visible light initiator, and biomedical applications are described.
Journal ArticleDOI
Amorphous polyphosphate, a smart bioinspired nano-/bio-material for bone and cartilage regeneration: towards a new paradigm in tissue engineering
TL;DR: PolyP in combination with other, hydrogel-forming polymers provides the basis for the fabrication of hardenable bio-inks applicable in additive manufacturing/3D printing and 3D cell bioprinting of regeneratively active patient-specific osteo-articular implants.
Journal ArticleDOI
From Arteries to Capillaries: Approaches to Engineering Human Vasculature
TL;DR: In this review, design considerations and technologies for engineering millimeter‐, meso‐, and microscale vessels are discussed and key challenges limiting the translation of vascularized tissues are identified.
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