3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Journal ArticleDOI
3D bioprinting for lung and tracheal tissue engineering: Criteria, advances, challenges, and future directions
TL;DR: The use of a universal bioink with a focus on decellularized-extracellular matrix, pluripotent stem cells, stereolithography printing method, and automated monitoring bioreactors are presented as future directions to accelerate achieving functional 3D-printed lungs and trachea for transplantation.
Journal ArticleDOI
3D printed hydrogel scaffolds with macro pores and interconnected microchannel networks for tissue engineering vascularization
Yongxiang Luo,Tao Zhang,Xin Lin +2 more
TL;DR: A facile method to effectively fabricate hydrogel scaffold containing designed macro pores and FIM networks by 3D printing and surface crosslinking is reported, which demonstrates their strong potential for tissue engineering application.
Journal ArticleDOI
Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy.
TL;DR: Extracellular vesicles (EVs) are membrane-delimited particles that are secreted by nearly all cell types and mediate crucial physiological functions and pathophysiological processes in the spinal cord injury as mentioned in this paper.
Journal ArticleDOI
Fast Stereolithography Printing of Large-Scale Biocompatible Hydrogel Models.
Nanditha Anandakrishnan,Hang Ye,Zipeng Guo,Zhaowei Chen,Kyle I Mentkowski,Kyle I Mentkowski,Jennifer K Lang,Jennifer K Lang,Nika Rajabian,Stelios T. Andreadis,Zhen Ma,Joseph A. Spernyak,Jonathan F. Lovell,Depeng Wang,Jun Xia,Chi Zhou,Ruogang Zhao +16 more
TL;DR: In this article, a fast hydrogel stereolithography printing (FLOAT) method is presented that allows the creation of a centimeter-sized, multiscale solid hydrogels model within minutes.
Journal ArticleDOI
3D Bioprinting of Vascularized Tissues for in vitro and in vivo Applications.
TL;DR: A review of the latest advancements in fabricating vascularized tissue and organs including novel strategies and materials, and their applications can be found in this article, where the main challenge of maintaining 3D printed tissue viability is the inclusion of complex vascular networks for nutrient transport and waste disposal.
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