3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Organ Printing: Tissue Spheroids as Building Blocks
Vladimir Mironov,Jing Zhang,Carmine Gentile,K Brakke,Thomas C. Trusk,Karoly Jakab,Gabor Forgacs,Vladimirs Kasjanovs,Richard P. Visconti,Roger R. Markwald +9 more
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
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Nanomaterial-Enabled Wearable Sensors for Healthcare.
TL;DR: Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review.
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3D bioprinting of tissues and organs for regenerative medicine.
TL;DR: The current status and contemporary issues of 3D bioprinting pertaining to the eleven organ systems of the human body including skeletal, muscular, nervous, lymphatic, endocrine, reproductive, integumentary, respiratory, digestive, urinary, and circulatory systems were critically reviewed.
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3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
TL;DR: This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015.
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Recent Advances in Biomaterials for 3D Printing and Tissue Engineering
TL;DR: Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors.
References
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Viability and electrophysiology of neural cell structures generated by the inkjet printing method.
TL;DR: In this study a new method was developed to create 3D cellular structures: sheets of neural cells were layered on each other (layer-by-layer process) by alternate inkjet printing of NT2 cells and fibrin gels.
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Neural tissue engineering options for peripheral nerve regeneration
TL;DR: New attempts in the design of template (or scaffold) materials are delineated, especially in the context of biocompatibility, the choice and handling of support cells, and growth factor release systems, to create a self-consistent coordinated system with a close proximity to the regenerative microenvironment of the peripheral nervous system.
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Cell and organ printing 1: Protein and cell printers
W. Cris Wilson,Thomas Boland +1 more
TL;DR: Modifications to the print heads, and the printer hardware and software that enabled us to adapt the ink-jet printers for the manufacture of cell and protein arrays are described.
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3D printing in pharmaceutics: A new tool for designing customized drug delivery systems
Jonathan Goole,Karim Amighi +1 more
TL;DR: This paper aims to review the processes that can be used in pharmaceutics, including the parameters to be controlled, to give an overview on the pragmatic tools, which can beused for designing customized drug delivery systems using 3D printing.
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4D Bioprinting for Biomedical Applications.
TL;DR: The uses of 4D bioprinting in tissue engineering and drug delivery, and the major roadblocks to this approach are discussed, together with possible solutions, to provide future perspectives on this technology.