3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Proceedings ArticleDOI
On-chip fabrication of movable toroidal cell structures using photo-crosslinkable biodegradable hydrogel
Masaru Takeuchi,Yuki Nakamura,Akihiko Ichikawa,Akiyuki Hasegawa,Yasuhisa Hasegawa,Toshio Fukuda +5 more
TL;DR: The results indicate that the fabricated movable GelMA microstructures can be used for further three dimensional assembly to achieve vascular-like tube structures.
Journal ArticleDOI
Extracellular Matrix by Design: Native Biomaterial Fabrication and Functionalization to Boost Tissue Regeneration
TL;DR: The extracellular matrix (ECM) is a "nest" established by cells in their surroundings, which is a microenvironment that supports cellular function and survival, as well as their collaboration with one another.
Journal ArticleDOI
Bioprinting small‐diameter vascular vessel with endothelium and smooth muscle by the approach of two‐step crosslinking process
TL;DR: Wang et al. as mentioned in this paper developed a new bioprinting approach to fabricating small-diameter vessel using two-step crosslinking process, where the precrosslinked flat structure was merged towards the uncrosslinked concave structure, and two individual structures were combined tightly into an intact tubular structure after receiving more UV exposure time.
Journal ArticleDOI
Cancer Cell Direct Bioprinting: A Focused Review.
TL;DR: In this paper, a review of the materials, the bioprinting technologies, and the cells used in cancer research for breast, brain, lung, liver, reproductive, gastric, skin, and bladder associated cancers, to help the development of possible treatments to lower the mortality rates, increasing the effectiveness of guided therapies.
Journal ArticleDOI
Self-Contained Three-Dimensional Bioprinter for Applications in Cardiovascular Research
TL;DR: The bioprinter system presented in this paper aims to facilitate the process of 3D bioprinting through its ability to control the environmental parameters within an enclosed printing chamber by regulating the necessary environmental conditions important for cell survival, especially during long duration prints.
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