3D Bioprinting for Organ Regeneration
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TLDR
An overview of recent advances in 3D biop printing technology, as well as design concepts of bioinks suitable for the bioprinting process, focusing more specifically on vasculature, neural networks, the heart and liver are provided.Abstract:
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.read more
Citations
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Organ Printing: Tissue Spheroids as Building Blocks
Vladimir Mironov,Jing Zhang,Carmine Gentile,K Brakke,Thomas C. Trusk,Karoly Jakab,Gabor Forgacs,Vladimirs Kasjanovs,Richard P. Visconti,Roger R. Markwald +9 more
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
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Nanomaterial-Enabled Wearable Sensors for Healthcare.
TL;DR: Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review.
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3D bioprinting of tissues and organs for regenerative medicine.
TL;DR: The current status and contemporary issues of 3D bioprinting pertaining to the eleven organ systems of the human body including skeletal, muscular, nervous, lymphatic, endocrine, reproductive, integumentary, respiratory, digestive, urinary, and circulatory systems were critically reviewed.
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3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
TL;DR: This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015.
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Recent Advances in Biomaterials for 3D Printing and Tissue Engineering
TL;DR: Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors.
References
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Engineering biological structures of prescribed shape using self-assembling multicellular systems
TL;DR: It is shown, both experimentally and by using computer simulations, how tissue liquidity can be used to build tissue constructs of prescribed geometry in vitro and suggested that spherical aggregates composed of organ-specific cells may be used as "bio-ink" in the evolving technology of organ printing.
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Creating perfused functional vascular channels using 3D bio-printing technology.
Vivian K. Lee,Diana Y. Kim,Haygan Ngo,Young Lee,Lan Seo,Seung-Schik Yoo,Peter A. Vincent,Guohao Dai +7 more
TL;DR: A methodology using 3D bio-printing technology to create a functional in vitro vascular channel with perfused open lumen using only cells and biological matrices to investigate fundamental mechanisms of vascular remodeling with extracellular matrix and maturation process under 3D flow condition.
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Direct-write bioprinting three-dimensional biohybrid systems for future regenerative therapies.
TL;DR: This review describes the current state-of-the-art bioprinting technologies and provides baseline direct-write printing parameters for a hydrogel system often used in cardiovascular applications to provide a useful foundation for colleagues to incorporate this 3D fabrication method into future regenerative therapies.
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Engineered whole organs and complex tissues.
TL;DR: Three-dimensional biological scaffolds made of allogeneic or xenogeneic extracellular matrix derived from non-autologous sources can act as an inductive template for functional tissue and organ reconstruction after recellularisation with autologous stem cells or differentiated cells.
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Small-diameter vascular tissue engineering
TL;DR: Advances in vascular tissue engineering technology—such as self-assembling cell sheets, as well as scaffold-guided and decellularized-matrix approaches—promise to produce responsive, living conduits with properties similar to those of native tissue.