A functional polymorphism in the monoamine oxidase A gene promoter
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TLDR
A new polymorphism upstream of the gene for monoamine oxidase A, which consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies, may be useful as both a functional and an anonymous genetic marker for MAOA.Abstract:
We describe a new polymorphism upstream of the gene for monoamine oxidase A (MAOA), an important enzyme in human physiology and behavior. The polymorphism, which is located 1.2 kb upstream of the MAOA coding sequences, consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism is in linkage disequilibrium with other MAOA and MAOB gene markers and displays significant variations in allele frequencies across ethnic groups. The polymorphism has been shown to affect the transcriptional activity of the MAOA gene promoter by gene fusion and transfection experiments involving three different cell types. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2–10 times more efficiently than those with 3 or 5 copies of the repeat, suggesting an optimal length for the regulatory region. This promoter region polymorphism may be useful as both a functional and an anonymous genetic marker for MAOA.read more
Citations
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Similarity in temperament between mother and offspring rhesus monkeys: Sex differences and the role of monoamine oxidase-a and serotonin transporter promoter polymorphism genotypes
Erin C. Sullivan,Erin C. Sullivan,Sally P. Mendoza,Sally P. Mendoza,John P. Capitanio,John P. Capitanio +5 more
TL;DR: The relationship between measures of temperament in mothers and their first-born offspring and the role of genetic sensitivity in establishing the strength of these associations is explored and a four-factor structure of temperament is revealed.
Journal ArticleDOI
Mitigating aggressiveness through education? The monoamine oxidase A genotype and mental health in general population.
Evelyn Kiive,Kariina Laas,Kirsti Akkermann,Erika Comasco,Lars Oreland,Toomas Veidebaum,Jaanus Harro +6 more
TL;DR: In a population representative sample of young subjects, the MAOA-uVNTR ‘risk genotype’ predicted better life outcomes as expressed in higher level of education.
Journal ArticleDOI
Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases
Riri Shi,Qiong Wu,Chenqi Xin,Houzhi Yu,Kah-Leong Lim,Xin Li,Zhenxiong Shi,Chengwu Zhang,Linghui Qian,Lin Li,Wei Huang,Wei Huang +11 more
TL;DR: In this review, progress in the detecting and inhibiting of MAOs and their applications in mechanism exploration and treatment of neurotransmitter‐related disorders is summarized.
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The Association Between the MAOA 2R Genotype and Delinquency Over Time Among Men: The Interactive Role of Parental Closeness and Parental Incarceration
TL;DR: It is concluded that the 2R-delinquency association is not due to passive gene–environment correlation but is best characterized as a social control Gene × Environment interaction.
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Arginine Vasopressin 1a Receptor (AVPR1a) RS3 Repeat Polymorphism Associated with Entrepreneurship
TL;DR: The genetic associations reported here identify AVPR1a and not DRD4 or MAOA as a potential candidate for future research into the genetic underpinnings of entrepreneurship, however, the results should be interpreted with caution given the sample size and the prevalence of false positives.
References
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Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
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