A functional polymorphism in the monoamine oxidase A gene promoter
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TLDR
A new polymorphism upstream of the gene for monoamine oxidase A, which consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies, may be useful as both a functional and an anonymous genetic marker for MAOA.Abstract:
We describe a new polymorphism upstream of the gene for monoamine oxidase A (MAOA), an important enzyme in human physiology and behavior. The polymorphism, which is located 1.2 kb upstream of the MAOA coding sequences, consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism is in linkage disequilibrium with other MAOA and MAOB gene markers and displays significant variations in allele frequencies across ethnic groups. The polymorphism has been shown to affect the transcriptional activity of the MAOA gene promoter by gene fusion and transfection experiments involving three different cell types. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2–10 times more efficiently than those with 3 or 5 copies of the repeat, suggesting an optimal length for the regulatory region. This promoter region polymorphism may be useful as both a functional and an anonymous genetic marker for MAOA.read more
Citations
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Book ChapterDOI
Genes and Human Decision-Making
Martin Reuter,Christian Montag +1 more
TL;DR: The present chapter aims to give a concise overview of the genetics of human decision-making by reviewing studies that can be considered within the field of neuroeconomics, and identifying theory-driven, distinct gene loci relevant for decision- making in economic contexts from the literature.
Journal ArticleDOI
The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia.
G. M. Zharinov,Sergei E Khalchitsky,Alexandre Loktionov,Marina V. Sogoyan,Yulia V Khutoryanskaya,Natalia Yu Neklasova,O A Bogomolov,Ilya V Smirnov,Marina P Samoilovich,Vladimir N Skakun,Sergei V. Vissarionov,Vladimir N. Anisimov +11 more
TL;DR: In this article, gene polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time (PSADT) corresponding to unfavorable and favorable disease prognosis respectively.
The role of the VNTR functional polymorphism of the promoter region of the MAOA gene on psychiatric disorders O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos
Silvia Alves Nishioka,Eduardo Aliende Perin,Aline S. Sampaio,Quirino Cordeiro,Carolina Cappi,Ivanil A. Morais,Viviane Neri,Souza Reis,Maria Conceição do Rosário,Ana Gabriela Hounie +9 more
TL;DR: In this paper, a review of the literature on the role of the VNTR functional polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene on the modulation of human behavior for the development of psychiatric disorders is presented.
Journal ArticleDOI
Distinct chromatin structures at the monoamine oxidase-A promoter correlate with allele-specific expression in SH-SY5Y cells.
Maurizio Manca,V. Pessoa,Paul Myers,Andrew Pickles,Jonathan Hill,Helen Sharp,Chris Murgatroyd,Vivien J. Bubb,John P. Quinn +8 more
TL;DR: Biochemically the model for MAOA promoter function has implications for gender differences in gene × environment responses in which the uVNTR has been implicated as a genetic risk.
References
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Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Klaus-Peter Lesch,D. Bengel,Armin Heils,Sue Z. Sabol,Benjamin D. Greenberg,Susanne Petri,Jonathan Benjamin,Clemens R. Müller,Dean H. Hamer,Dennis L. Murphy +9 more
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Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
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Journal ArticleDOI
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking
Jonathan Benjamin,Lin Li,Chavis Patterson,Benjamin D. Greenberg,Dennis L. Murphy,Dean H. Hamer +5 more
TL;DR: The relationship between DADR exon III sequence variants and personality test scores in a population of 315 mostly male siblings, other family members and individuals from the United States was investigated and the association between long alleles ofExon III and personality traits related to Novelty Seeking was confirmed.
Journal ArticleDOI
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.