A knowledgebase resource for interleukin-17 family mediated signaling
Jyoti Sharma,Lavanya Balakrishnan,Keshava K. Datta,Nandini A. Sahasrabuddhe,Aafaque Ahmad Khan,Apeksha Sahu,Anish Singhal,Anish Singhal,Derese Getnet,Rajesh Raju,Aditi Chatterjee,Harsha Gowda,T. S. Keshava Prasad,Subramanian Shankar,Akhilesh Pandey +14 more
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TLDR
This study presents a resource of literature-annotated reactions induced by IL-17, and catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation.Abstract:
Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.read more
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A Review of Biologic Therapies Targeting IL-23 and IL-17 for Use in Moderate-to-Severe Plaque Psoriasis
TL;DR: The development of several highly effective biologic drugs in the past decade has revolutionized the treatment of moderate-to-severe plaque psoriasis and current models emphasize the significant importance of interleukin (IL)-23 and IL-17.
Journal ArticleDOI
A network map of Interleukin-10 signaling pathway.
Renu Verma,Lavanya Balakrishnan,Kusum Sharma,Aafaque Ahmad Khan,Jayshree Advani,Harsha Gowda,Srikanth Tripathy,Mrutyunjay Suar,Akhilesh Pandey,Sheetal Gandotra,T. S. Keshava Prasad,T. S. Keshava Prasad,Subramanian Shankar +12 more
TL;DR: A pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature was developed, which can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by the group.
Journal ArticleDOI
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
TL;DR: There is intensive investigation into the role of ILC2s in human disease with the hope of a better understanding of the pathophysiology and the discovery of novel potential therapeutic targets.
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An overview of the oxytocin-oxytocin receptor signaling network
Oishi Chatterjee,Krutika Patil,Apeksha Sahu,Lathika Gopalakrishnan,Praseeda Mol,Jayshree Advani,Srabani Mukherjee,Rita Christopher,T. S. Keshava Prasad,T. S. Keshava Prasad +9 more
TL;DR: Oxytocin signaling network data is made freely available to academic fraternity by integrating this into NetPath (http://www.netpath.org/), a freely available human signaling pathway resource developed previously by the group.
Journal ArticleDOI
Lipid mediators as regulators of human ILC2 function in allergic diseases
Viktoria Konya,Jenny Mjösberg +1 more
TL;DR: Current knowledge about ILC2 biology in the allergy context is summarized, with a particular focus on the emerging role of lipid mediators in regulating ILC1-like phenotype and the role of epithelial cell-derived innate cytokines and bioactive lipids.
References
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Journal ArticleDOI
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
Paul Shannon,Andrew Markiel,Owen Ozier,Nitin S. Baliga,Jonathan T. Wang,Daniel Ramage,Nada Amin,Benno Schwikowski,Trey Ideker +8 more
TL;DR: Several case studies of Cytoscape plug-ins are surveyed, including a search for interaction pathways correlating with changes in gene expression, a study of protein complexes involved in cellular recovery to DNA damage, inference of a combined physical/functional interaction network for Halobacterium, and an interface to detailed stochastic/kinetic gene regulatory models.
Journal ArticleDOI
IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
Journal ArticleDOI
Evolving concepts of rheumatoid arthritis
TL;DR: Based on the pathogenic mechanisms, specific therapeutic interventions can be designed to suppress synovial inflammation and joint destruction in rheumatoid arthritis.
Journal ArticleDOI
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.
Michael Hucka,Andrew Finney,Herbert M. Sauro,Hamid Bolouri,Hamid Bolouri,John Doyle,Hiroaki Kitano,Adam P. Arkin,Benjamin Bornstein,Dennis Bray,Athel Cornish-Bowden,Autumn A. Cuellar,S. Dronov,E. D. Gilles,Martin Ginkel,V. Gor,Igor Goryanin,W. J. Hedley,T. C. Hodgman,J.-H.S. Hofmeyr,Peter Hunter,Nick Juty,J. L. Kasberger,Andreas Kremling,Ursula Kummer,N Le Novère,Leslie M. Loew,D. Lucio,Pedro Mendes,E. Minch,Eric Mjolsness,Yoichi Nakayama,Melanie R. Nelson,Poul M. F. Nielsen,T. Sakurada,James C. Schaff,Bruce E. Shapiro,Thomas S. Shimizu,H. D. Spence,Jörg Stelling,Koichi Takahashi,Masaru Tomita,John Wagner,J. Wang +43 more
TL;DR: This work summarizes the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks, a software-independent language for describing models common to research in many areas of computational biology.
Journal ArticleDOI
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
TL;DR: The factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.