An overview of the oxytocin-oxytocin receptor signaling network
Oishi Chatterjee,Krutika Patil,Apeksha Sahu,Lathika Gopalakrishnan,Praseeda Mol,Jayshree Advani,Srabani Mukherjee,Rita Christopher,T. S. Keshava Prasad,T. S. Keshava Prasad +9 more
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TLDR
Oxytocin signaling network data is made freely available to academic fraternity by integrating this into NetPath (http://www.netpath.org/), a freely available human signaling pathway resource developed previously by the group.Abstract:
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions. However, a well annotated map of oxytocin signaling pathway is currently lacking in the publicly available pathway resources. Therefore, we systematically curated the available signaling information of oxytocin from published literature and collated the data to develop a more complete map. We cataloged 66 molecules belonging to oxytocin signaling pathway, which included 9 protein-protein interactions, 39 post-translational modifications, 14 protein translocation events and 22 activation/inhibition events. Further, Oxytocin signaling network data is made freely available to academic fraternity by integrating this into NetPath ( http://www.netpath.org /), a freely available human signaling pathway resource developed previously by our group.read more
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Book ChapterDOI
Overview of Human Oxytocin Research
TL;DR: Clinical findings while somewhat varied in outcome do offer increasing cause for optimism that targeting the oxytocin system may provide a successful therapeutic approach for social dysfunction, however, future research needs to focus on the most effective treatment strategy and which types of individuals are likely to benefit most.
Journal ArticleDOI
Comprehensive network map of interferon gamma signaling.
Mohd Younis Bhat,Hitendra S. Solanki,Jayshree Advani,Aafaque Ahmad Khan,T. S. Keshava Prasad,Harsha Gowda,Saravanan Thiyagarajan,Aditi Chatterjee +7 more
TL;DR: The aim of this work is to systematically curated the literature information pertaining to IFN-γ signaling and develop a comprehensive signaling network to facilitate better understanding of IFn-γ mediated signaling and facilitate further research in IF-γ associated human diseases including cancer.
Journal ArticleDOI
Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin
TL;DR: A new important role of OXT is attributed in neuroprotection through the microglia–OXT interaction of immature and adult brains through the inhibition of production of pro-inflammatory mediators, and in the development of correct neural circuitry.
Journal ArticleDOI
Oxytocin and cancer: An emerging link.
TL;DR: Observations linking oxytocin and cancer are summarized, with a special emphasis on prostate cancer, where it may promote cell proliferation and future research is needed to further elucidate the involvement of oxytoc in cancer, and whether it could be a clinical cancer biomarker or therapeutic target.
Journal ArticleDOI
Links Between the Neurobiology of Oxytocin and Human Musicality
TL;DR: It is argued that many of these characteristics of oxytocin biology closely mirror the diverse effects that music has on human cognition and emotion, providing a link to the important role music has played throughout human evolutionary history and helping to explain why music remains a special prosocial human asset.
References
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Journal ArticleDOI
The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
Journal ArticleDOI
The BioPAX community standard for pathway data sharing
Emek Demir,Emek Demir,Michael P. Cary,Suzanne M. Paley,Ken Fukuda,Christian Lemer,Imre Vastrik,Guanming Wu,Peter D'Eustachio,Carl F. Schaefer,Joanne S. Luciano,Frank Schacherer,Irma Martínez-Flores,Zhenjun Hu,Verónica Jiménez-Jacinto,Geeta Joshi-Tope,Kumaran Kandasamy,Alejandra López-Fuentes,Huaiyu Mi,Elgar Pichler,Igor Rodchenkov,Andrea Splendiani,Andrea Splendiani,Sasha Tkachev,Jeremy Zucker,Gopal R. Gopinath,Harsha Rajasimha,Harsha Rajasimha,Ranjani Ramakrishnan,Imran Shah,Mustafa H Syed,Nadia Anwar,Özgün Babur,Özgün Babur,Michael L. Blinov,Erik Brauner,Dan Corwin,Sylva L. Donaldson,Frank Gibbons,Robert N. Goldberg,Peter Hornbeck,Augustin Luna,Peter Murray-Rust,Eric K. Neumann,Oliver Reubenacker,Matthias Samwald,Matthias Samwald,Martijn P. van Iersel,Sarala M. Wimalaratne,Keith Allen,Burk Braun,Michelle Whirl-Carrillo,Kei-Hoi Cheung,Kam D. Dahlquist,Andrew Finney,Marc Gillespie,Elizabeth M. Glass,Li Gong,Robin Haw,Michael Honig,Olivier Hubaut,David W. Kane,Shiva Krupa,Martina Kutmon,Julie Leonard,Debbie Marks,David Merberg,Victoria Petri,Alexander R. Pico,Dean Ravenscroft,Liya Ren,Nigam H. Shah,Margot Sunshine,Rebecca Tang,Ryan Whaley,Stan Letovksy,Kenneth H. Buetow,Andrey Rzhetsky,Vincent Schächter,Bruno S. Sobral,Ugur Dogrusoz,Shannon K. McWeeney,Mirit I. Aladjem,Ewan Birney,Julio Collado-Vides,Susumu Goto,Michael Hucka,Nicolas Le Novère,Natalia Maltsev,Akhilesh Pandey,Paul Thomas,Edgar Wingender,Peter D. Karp,Chris Sander,Gary D. Bader +94 more
TL;DR: Thousands of interactions, organized into thousands of pathways, from many organisms are available from a growing number of databases, and this large amount of pathway data in a computable form will support visualization, analysis and biological discovery.
Journal ArticleDOI
NetPath: a public resource of curated signal transduction pathways
Kumaran Kandasamy,Subburaman Mohan,Rajesh Raju,Shivakumar Keerthikumar,Ghantasala S. Sameer Kumar,Abhilash K. Venugopal,Deepthi Telikicherla,Daniel J. Navarro,Suresh Mathivanan,Christian Pecquet,Sashi Kanth Gollapudi,Sudhir Gopal Tattikota,Shyam Mohan,Hariprasad Padhukasahasram,Yashwanth Subbannayya,Renu Goel,Harrys K.C. Jacob,Jun Zhong,Raja Sekhar,Vishalakshi Nanjappa,Lavanya Balakrishnan,Roopashree Subbaiah,Y. L. Ramachandra,B. Abdul Rahiman,T. S. Keshava Prasad,Jian Xin Lin,Jon C. D. Houtman,Stephen Desiderio,Jean-Christophe Renauld,Stefan N. Constantinescu,Osamu Ohara,Toshio Hirano,Masato Kubo,S. Singh,Purvesh Khatri,Sorin Draghici,Gary D. Bader,Gary D. Bader,Chris Sander,Warren J. Leonard,Akhilesh Pandey +40 more
TL;DR: NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles.
Journal ArticleDOI
Oxytocin receptors: triggers for parturition and lactation?
TL;DR: Ovarian steroids participate in the regulation of oxytocin receptors in a manner as yet unclarified and may regulate the response of the target organs to circulating Oxytocin and thereby control the onset of labor and lactation.
Book ChapterDOI
Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis.
TL;DR: In the present chapter, the efforts to reveal the physiological significance of intracerebrally released oxytocin in rats with respect to the regulation of the HPA axis under basal and stress conditions as well as withrespect to behavioural stress responses are summarized.
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The Oxytocin Receptor System: Structure, Function, and Regulation
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The BioPAX community standard for pathway data sharing
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