Journal ArticleDOI
A new ratiometric fluorescent probe for rapid, sensitive and selective detection of endogenous hydrogen sulfide in mitochondria.
TLDR
A new ratiometric fluorescent probe composed of a coumarin-merocyanine dyad based on the FRET mechanism showed clear dual-emission signal changes in blue and red spectral windows upon addition of H2S in a dose dependent manner under a single wavelength excitation.About:
This article is published in Chemical Communications.The article was published on 2016-02-11. It has received 151 citations till now.read more
Citations
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Journal ArticleDOI
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
Jacek Zielonka,Joy Joseph,Adam Sikora,Micael Hardy,Olivier Ouari,Jeannette Vasquez-Vivar,Gang Cheng,Marcos Lopez,Balaraman Kalyanaraman +8 more
TL;DR: The physicochemical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochondrial probes, and sensors, and examples of mitochondrial targeting of bioactive compounds are described.
Journal ArticleDOI
Coumarin-Based Small-Molecule Fluorescent Chemosensors.
Duxia Cao,Zhiqiang Liu,Peter Verwilst,Seyoung Koo,Paramesh Jangjili,Jong Seung Kim,Weiying Lin,Weiying Lin +7 more
TL;DR: This comprehensive and critical review of coumarin-based small-molecule fluorescent chemosensors during the period of 2012-2018 may facilitate the development of more powerful fluorescent chemOSensors for broad and exciting applications in the future.
Journal ArticleDOI
Fluorescent probes for organelle-targeted bioactive species imaging
TL;DR: The design, applications, challenges and potential directions of organelle-targeted bioactive species probes are described.
Journal ArticleDOI
A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells
TL;DR: A multi-signal fluorescent probe was engineered for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells.
Journal ArticleDOI
Small-molecule fluorescent probes and their design
Yanhua Fu,Nathaniel S. Finney +1 more
TL;DR: This tutorial review introduces some important concepts related to fluorescent probe development and is hoped that it will facilitate further expansion of the field by demystifying it.
References
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Journal ArticleDOI
H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Guangdong Yang,Guangdong Yang,Lingyun Wu,Bo Jiang,Wei Yang,Jiansong Qi,Kun Cao,Qinghe Meng,Asif K. Mustafa,Weitong Mu,Shengming Zhang,Solomon H. Snyder,Rui Wang,Rui Wang +13 more
TL;DR: It is shown that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues.
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The possible role of hydrogen sulfide as an endogenous neuromodulator
Kazuho Abe,Hideo Kimura +1 more
TL;DR: It is shown that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation, suggesting that endogenous H 2S functions as a neuromodulator in the brain.
Journal ArticleDOI
Design strategies for water-soluble small molecular chromogenic and fluorogenic probes.
Journal ArticleDOI
Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules
TL;DR: An overview of the design principles underlying small fluorescent probes that have been applied to the ratiometric detection of various analytes, including cations, anions, and biomolecules in solution and in biological samples are provided.
Journal ArticleDOI
Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems
TL;DR: Access to this growing chemical toolbox of new molecular probes for H2S and related RSS sets the stage for applying these developing technologies to probe reactive sulfur biology in living systems.