A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
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TLDR
Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.About:
This article is published in Cell Stem Cell.The article was published on 2008-09-11 and is currently open access. It has received 3638 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Adult stem cell.read more
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Biologic approaches to enhance rotator cuff healing after injury
TL;DR: Use of growth factors, stem cell therapy, and other tissue-engineering means serve to augment classical surgical rotator cuff repair procedures, reflecting paucity of research in this field.
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Analysis of αSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing
Brya G. Matthews,Danka Grčević,Liping Wang,Yusuke Hagiwara,Hrvoje Roguljić,Pujan Joshi,Dong-Guk Shin,Douglas J. Adams,Ivo Kalajzic +8 more
TL;DR: It is shown that modulation of Notch signaling may determine osteogenic potential of αSMA‐expressing progenitor cells during bone healing, and activating Notch signaled inhibited differentiation into osteogenic and adipogenic lineages in vitro and ectopic bone formation in vivo.
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Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair.
TL;DR: The challenges associated with cartilage repair and regeneration using MSC-based cell therapies are explored and an overview of phenotype, biological activities, and functional properties for each MSC population is provided.
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Concise Review: MicroRNA Function in Multipotent Mesenchymal Stromal Cells
TL;DR: This review presents in detail miRNAs with overlapping effects (i.e., common target genes) and discusses future directions to deepen the understanding of miRNA biology in MSC.
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High Harvest Yield, High Expansion, and Phenotype Stability of CD146 Mesenchymal Stromal Cells from Whole Primitive Human Umbilical Cord Tissue
Rebecca C. Schugar,Steven M. Chirieleison,Kristin E. Wescoe,Benjamin T. Schmidt,Yuko S. Askew,Jordan J. Nance,Joshua M. Evron,Bruno Péault,Bridget M. Deasy +8 more
TL;DR: The remarkable stability of the phenotype represents a novel finding for human MSCs, from any source, and supports the use of these cells as highly accessible stromal cells for both basic studies and potentially therapeutic applications such as allogeneic clinical use for musculoskeletal disorders.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
TL;DR: It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.