A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
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TLDR
Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.About:
This article is published in Cell Stem Cell.The article was published on 2008-09-11 and is currently open access. It has received 3638 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Adult stem cell.read more
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Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.
Iain R. Murray,James Baily,William C.W. Chen,Ayelet Dar,Z. Gonzalez,Andrew R. Jensen,Frank A. Petrigliano,Arjun Deb,Neil C. Henderson +8 more
TL;DR: Skeletal muscle and cardiac pericytes are now recognized to fulfill an increasing number of functions in normal tissue homeostasis, including contributing to microvascular function by maintaining vessel stability and regulating capillary flow.
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Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction
Bianca Vezzani,Isaac Shaw,Hanna Lesme,Li Yong,Nusrat Khan,Carlo Tremolada,Bruno Péault,Bruno Péault +7 more
TL;DR: In culture, microfragmented adipose tissue releases many more growth factors and cytokines involved in tissue repair and regeneration, noticeably via angiogenesis, compared to isogenic SVF, and it is suggested that the efficient tissue repair/regeneration observed after transplantation ofmicrofragments is due to the secretory ability of the intact perivascular niche.
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Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke
Noriko Makihara,Koichi Arimura,Tetsuro Ago,Masaki Tachibana,Ataru Nishimura,Kuniyuki Nakamura,Ryu Matsuo,Yoshinobu Wakisaka,Junya Kuroda,Hiroshi Sugimori,Masahiro Kamouchi,Takanari Kitazono +11 more
TL;DR: The expression level of PDGFRβ may be a crucial determinant of fibrosis after ischemic stroke, as it participates in the production of fibronectin and collagen type I after isChemic stroke.
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Q&A: Mesenchymal stem cells - where do they come from and is it important?
TL;DR: This work states that candidate native MSCs have been identified within fetal and adult organs and may have important positive consequences for the therapeutic use of these cells.
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Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs.
Mattia Quattrocelli,Giacomo Palazzolo,Giuseppe Floris,Patrick Schöffski,Luigi Anastasia,Aldo Orlacchio,Thierry VandenDriessche,Thierry VandenDriessche,Marinee Chuah,Marinee Chuah,Giulio Cossu,Catherine M. Verfaillie,Maurilio Sampaolesi,Maurilio Sampaolesi +13 more
TL;DR: The data strongly suggest that iPSCs are a heterogeneous population and, when generated from myogenic adult stem cells, they exhibit a stronger commitment, paving the way for creating custom‐made cell protocols for muscular dystrophies.
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
TL;DR: It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.