A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
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TLDR
Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.About:
This article is published in Cell Stem Cell.The article was published on 2008-09-11 and is currently open access. It has received 3638 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Adult stem cell.read more
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Structure and Functions of Blood Vessels and Vascular Niches in Bone
TL;DR: Recent developments in the understanding of vascular niches in bone that play a critical role in regulating the behaviour of multipotent haematopoietic and mesenchymal stem cells during development and homeostasis are discussed.
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Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics.
Junjie Wu,Junjie Wu,Yun Sun,Yun Sun,Travis J. Block,Milos Marinkovic,Zhi Liang Zhang,Zhi Liang Zhang,Richard Chen,Yixia Yin,Yixia Yin,Juquan Song,David D. Dean,Zhongding Lu,Xiao Dong Chen,Xiao Dong Chen +15 more
TL;DR: Results indicate that UCB may be a virtually unlimited source of NHSCs when combined with isolation and expansion on ECM, andNHSCs May be a practical alternative to embryonic stem cells for a number of therapeutic applications.
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Fractionation of an ECM hydrogel into structural and soluble components reveals distinctive roles in regulating macrophage behavior
Peter F. Slivka,Christopher L. Dearth,Timothy J. Keane,F. W. Meng,Christopher J. Medberry,R. T. Riggio,R. T. Riggio,Janet E. Reing,Stephen F. Badylak +8 more
TL;DR: It is demonstrated that soluble and structural components of ECM hydrogels contribute to the host response but through different mechanisms.
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Transgenerational inheritance of prenatal obesogen exposure
TL;DR: Transgenerational effects of chemical exposure raise the stakes in the debate about whether and how endocrine disrupting chemicals should be regulated, including obesity in offspring after exposure of pregnant F0 females.
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Modulation of mesenchymal stromal cell characteristics by microcarrier culture in bioreactors
Julia Hupfeld,Ingo H. Gorr,Christian Schwald,Nicola Beaucamp,Kornelius Wiechmann,Karin Kuentzer,Ralf Huss,Bernhard Rieger,Markus Neubauer,Heike Wegmeyer +9 more
TL;DR: MC‐based MSC expansion in controlled bioreactors has the potential to reliably produce MSCs with altered characteristics and functions as compared to flask‐expanded MSCm, and these findings may be useful for the generation of M SCs with tailored properties for clinical applications.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
TL;DR: It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.