A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
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TLDR
Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.About:
This article is published in Cell Stem Cell.The article was published on 2008-09-11 and is currently open access. It has received 3638 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Adult stem cell.read more
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Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations.
TL;DR: The challenges that must be overcome before MSC-based tissue engineering can become a front-line technology for successful articular cartilage regeneration are highlighted.
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Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly
Paola Romina Amable,Marcus Vinicius Telles Teixeira,Rosana Bizon Vieira Carias,José Mauro Granjeiro,Radovan Borojevic +4 more
TL;DR: Mesenchymal stromal cells purified from different tissues have different angiogenic, inflammatory and matrix remodeling potential properties and these abilities should be further characterized in order to choose the best protocols for their therapeutic use.
Journal ArticleDOI
Renal interstitial fibrosis: mechanisms and evaluation.
Alton B. Farris,Robert B. Colvin +1 more
TL;DR: Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IFTA) as the final common pathway.
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Differentiation of multipotent vascular stem cells contributes to vascular diseases
Zhenyu Tang,Aijun Wang,Aijun Wang,Falei Yuan,Zhiqiang Yan,Bo Liu,Julia S. Chu,Jill A. Helms,Song Li +8 more
TL;DR: Evidence is provided that the differentiation of MVSCs, rather than the de-differentiation of SMCs, contributes to vascular remodeling and diseases, and this hypothesis is supported.
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Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells
Valeria V. Orlova,Francijna E. van den Hil,Sandra Petrus-Reurer,Yvette Drabsch,Peter ten Dijke,Christine L. Mummery +5 more
TL;DR: This protocol describes the efficient generation of ECs and pericytes from human pluripotent stem cells (hPSCs) under defined conditions and describes two assays for functional evaluation of hPSC-derived ECs.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
TL;DR: It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.