A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
Reads0
Chats0
TLDR
Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.About:
This article is published in Cell Stem Cell.The article was published on 2008-09-11 and is currently open access. It has received 3638 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Adult stem cell.read more
Citations
More filters
Journal ArticleDOI
Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin
Alessandra Rossini,Caterina Frati,Costanza Lagrasta,Gallia Graiani,Alessandro Scopece,Stefano Cavalli,Ezio Musso,Marco Baccarin,Marina Di Segni,Francesco Fagnoni,Antonia Germani,Eugenio Quaini,Manuel Mayr,Qingbo Xu,Andrea Barbuti,Dario DiFrancesco,Giulio Pompilio,Federico Quaini,Carlo Gaetano,Maurizio C. Capogrossi +19 more
TL;DR: Comparisons of in vitro and in vivo properties of adult human cardiac stromal cells (CStC) to those of syngeneic BMStC demonstrate that although CStC and BMstC share a commonStromal phenotype, C StC present cardiovascular-associated features and may represent an important cell source for more efficient cardiac repair.
Journal ArticleDOI
Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue
Anjali P. Kusumbe,Anjali P. Kusumbe,Saravana K. Ramasamy,Saravana K. Ramasamy,Andrea Staršíchová,Andrea Staršíchová,Ralf H. Adams,Ralf H. Adams +7 more
TL;DR: This procedure involves tissue fixation, decalcification and cryosectioning of the mouse skeletal tissue to generate thick sections that are compatible with the analysis of genetically expressed fluorescent proteins but they also preserve antigenicity, thus enabling diverse combinations of antibody labeling.
Journal ArticleDOI
Coculture of dental pulp stem cells with endothelial cells enhances osteo-/odontogenic and angiogenic potential in vitro.
Waruna Lakmal Dissanayaka,Xuan Zhan,Xuan Zhan,Chengfei Zhang,Kenneth M. Hargreaves,Lijian Jin,Edith H.Y. Tong +6 more
TL;DR: Direct coculture of DPSCs and ECs enhances the in vitro differentiation toward osteo-/odontogenic and angiogenic phenotypes and stabilized preexisting vessel-like structures formed by ECs and increased the longevity of them.
Journal ArticleDOI
Overexpression of Platelet-Derived Growth Factor-BB Increases Tumor Pericyte Content via Stromal-Derived Factor-1α/CXCR4 Axis
Nan Song,Yujie Huang,Hubing Shi,Shaopeng Yuan,Yanping Ding,Xiaomin Song,Yan Fu,Yongzhang Luo +7 more
TL;DR: The results highlight that the involvement of SDF-1alpha/CXCR4 axis is essential for the pericyte recruitment within the PDGF-BB-overexpressing tumor xenograft models and raise the possibility that blockade of the SDF -1alpha-CX CR4 axis may provide a therapeutic synergy with antiangiogenic molecules that selectively target ECs.
Journal ArticleDOI
Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery
Luca Anna Bors,Franciska Erdő +1 more
TL;DR: With these techniques more effective and even safer drugs can be developed for the treatment of devastating brain disorders, both technological and mechanistic tools are available to assist in overcoming the blood–brain barrier.
References
More filters
Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
Journal ArticleDOI
Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
Journal ArticleDOI
Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
Journal ArticleDOI
Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
TL;DR: It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.