A PPAR-independent pathway to PUFA-induced COX-2 expression
TLDR
The results demonstrate a pathway to the induction of COX-2 by PUFAs requiring NF-kappaB but not PPAR or PKC, and the PPAR-independent effect of PUFA was mimicked by the PKC activators 4beta-PMA and prostaglandin F(2alpha), but was not blocked by thePKC inhibitor RO318425.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 2008-06-11 and is currently open access. It has received 15 citations till now. The article focuses on the topics: PPAR agonist & Reporter gene.read more
Citations
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Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis.
Reinaldo González-Ramos,Anne Van Langendonckt,Sylvie Defrère,Jean-Christophe Lousse,Sébastien Colette,Luigi Devoto,Jacques Donnez +6 more
TL;DR: In this article, the role of NF-κB in the pathogenesis of endometriosis has been evaluated using a literature search conducted in PubMed to identify all relevant citations, highlighting the important role of NGF in the pathwayophysiology of Endometria.
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Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases.
TL;DR: The current understanding of the effects as well as the underlying mechanisms of ω-3 PUFAs on autoimmune diseases is summarized.
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Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin
Christopher L. Gentile,Dong Wang,Kyle T. Pfaffenbach,R. Cox,Yuren Wei,Michael J. Pagliassotti +5 more
TL;DR: The nature and mechanisms of fatty acid-mediated regulation of CREBh, a recently identified transcription factor that appears to be required for hepatic synthesis of C-reactive protein, are examined, establishing a potential molecular link between fatty acids and inflammation.
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Conjugated linoleic acids attenuate FSH- and IGF1-stimulated cell proliferation; IGF1, GATA4, and aromatase expression; and estradiol-17β production in buffalo granulosa cells involving PPARγ, PTEN, and PI3K/Akt
Isha Sharma,Dheer Singh +1 more
TL;DR: This study demonstrated the cross talk between downstream signaling of CLA and important hormone regulators of endocrine system, i.e. FSH and IGF1, on buffalo granulosa cell function (proliferation and steroidogenesis) and found that CLA intervenes the IGF1 signaling by decreasing p-Akt.
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Angiotensin II activates the calcineurin/NFAT signaling pathway and induces cyclooxygenase-2 expression in rat endometrial stromal cells.
TL;DR: Angiotensin II induced Cox-2 gene expression by activating the calcineurin/NFAT signaling pathway in endometrial stromal cells of non-pregnant but not of early-p Regnant rats, which might be related to differential roles that COX-2 plays in the endometrium.
References
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Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB
TL;DR: Band‐shift experiments identified the ethanolic leaf extracts of Artemisia ludoviciana ssp.
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Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.
TL;DR: The result presented herein implies that the receptor-mediated release of unsaturated fatty acids from phospholipids may take part, in synergy with diacylglycerol, in the activation of PKC even when the Ca2+ concentration is low.
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Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells.
TL;DR: It is demonstrated that fatty acids, prostaglandins, and non-steroidal anti-inflammatory drugs, compounds that are substrates, products, and inhibitors, respectively, of COX enzymatic activity, also increase its expression, and a region of the COX-2 promoter containing a peroxisome proliferator response element that is responsible for the enhancement of COx-2 expression is identified.
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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
TL;DR: This review summarizes the current state of knowledge on the possible second messenger function of arachidonate with specific emphasis on the regulation of protein kinase C.
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Cellular Enrichment with Polyunsaturated Fatty Acids Induces an Oxidative Stress and Activates the Transcription Factors AP1 and NFκB
TL;DR: The results indicate that the accumulation of PUFA from (n-6) and ( n-3) series elicited an intracellular oxidative stress, resulting in the activation of oxidative stress-responsive transcription factors such as AP1 and NFkappaB.