A PPAR-independent pathway to PUFA-induced COX-2 expression
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TLDR
The results demonstrate a pathway to the induction of COX-2 by PUFAs requiring NF-kappaB but not PPAR or PKC, and the PPAR-independent effect of PUFA was mimicked by the PKC activators 4beta-PMA and prostaglandin F(2alpha), but was not blocked by thePKC inhibitor RO318425.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 2008-06-11 and is currently open access. It has received 15 citations till now. The article focuses on the topics: PPAR agonist & Reporter gene.read more
Citations
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Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis.
Reinaldo González-Ramos,Anne Van Langendonckt,Sylvie Defrère,Jean-Christophe Lousse,Sébastien Colette,Luigi Devoto,Jacques Donnez +6 more
TL;DR: In this article, the role of NF-κB in the pathogenesis of endometriosis has been evaluated using a literature search conducted in PubMed to identify all relevant citations, highlighting the important role of NGF in the pathwayophysiology of Endometria.
Journal ArticleDOI
Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases.
TL;DR: The current understanding of the effects as well as the underlying mechanisms of ω-3 PUFAs on autoimmune diseases is summarized.
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Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin
Christopher L. Gentile,Dong Wang,Kyle T. Pfaffenbach,R. Cox,Yuren Wei,Michael J. Pagliassotti +5 more
TL;DR: The nature and mechanisms of fatty acid-mediated regulation of CREBh, a recently identified transcription factor that appears to be required for hepatic synthesis of C-reactive protein, are examined, establishing a potential molecular link between fatty acids and inflammation.
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Conjugated linoleic acids attenuate FSH- and IGF1-stimulated cell proliferation; IGF1, GATA4, and aromatase expression; and estradiol-17β production in buffalo granulosa cells involving PPARγ, PTEN, and PI3K/Akt
Isha Sharma,Dheer Singh +1 more
TL;DR: This study demonstrated the cross talk between downstream signaling of CLA and important hormone regulators of endocrine system, i.e. FSH and IGF1, on buffalo granulosa cell function (proliferation and steroidogenesis) and found that CLA intervenes the IGF1 signaling by decreasing p-Akt.
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Angiotensin II activates the calcineurin/NFAT signaling pathway and induces cyclooxygenase-2 expression in rat endometrial stromal cells.
TL;DR: Angiotensin II induced Cox-2 gene expression by activating the calcineurin/NFAT signaling pathway in endometrial stromal cells of non-pregnant but not of early-p Regnant rats, which might be related to differential roles that COX-2 plays in the endometrium.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
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Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.
TL;DR: A novel mechanism by which fatty acids modulate signaling pathways and target gene expression is represented by both SFA-induced COX-2 expression and its inhibition by UFAs are mediated through a common signaling pathway derived from Tlr4.
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Genetic Analysis with Man-Mouse Somatic Cell Hybrids: Linkage between Human Lactate Dehydrogenase B and Peptidase B Genes
TL;DR: Evidence of an active linkage between the human genes that control lactate dehydrogenase B and peptidase B is presented, but it is concluded that there is no link between the genes for lactate dehydration A and lactatehydrogenase A.
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Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA A FUNCTIONAL ANALYSIS OF THE MALIC ENZYME GENE PPAR RESPONSE ELEMENT
TL;DR: It is demonstrated that only MEp and not MEd is able to bind PPAR/retinoid X receptor (RXR) heterodimers and mediate peroxisome proliferator signaling.