A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse
Michelle L. Gottsch,Matthew Cunningham,Jeremy Troy Smith,Simina M. Popa,Blake V. Acohido,William F. Crowley,Stephanie B. Seminara,Donald K. Clifton,Robert A. Steiner +8 more
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TLDR
Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54, and it is concluded that kisspeptin-GPR54 signaling may be part of the hypothalamus circuitry that governs the hypothalamic secretion of GnRH.Abstract:
Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and mice, suggesting that kisspeptin signaling may be important for the regulation of gonadotropin secretion. To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically active C-terminal decapeptide) on gonadotropin secretion in the mouse, we administered the kisspeptins directly into the lateral cerebral ventricle of the brain and demonstrated that both peptides stimulate LH secretion. Further characterization of kisspeptin-54 demonstrated that it stimulated both LH and FSH secretion, at doses as low as 1 fmol; moreover, this effect was shown to be blocked by pretreatment with acyline, a potent GnRH antagonist. To learn more about the functional anatomy of kisspeptins, we mapped the distribution of KiSS-1 mRNA in the hypothalamus. We observed that KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus. We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH.read more
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Molecular characterization and expression of Kiss2/Kiss2r during embryonic and larval development in (Megalobrama amblycephala Yih, 1955)
TL;DR: The results suggest that the Kiss2/Kiss2r system has varied potential for influencing embryonic and larval development in fish species.
Journal ArticleDOI
Evaluation of Kisspeptin Level in Non Obstructive Azoospermic Patients
TL;DR: Kisspeptin level is lower in non-obstructive azoospermic infertile males than the fertile controls, so it might be used as a diagnostic tool for infertility and treatment of infertility disorders in patients proved to have a low level of kisspeptin hormone.
Journal Article
Comparison of the effects of kisspeptin-10 or gnrh on luteinizing hormone secretion during the luteal phase of the oestrous cycle in swamp buffalo cows
T. Chaikhun-Marcou,Pongsiwa Sotthibandhu,W. Suthikrai,R. Jintana,P. Makoom,Siriwat Suadsong,F. De Rensis +6 more
TL;DR: It is indicated that during the luteal phase of the estrous cycle, administration of GnRH, but not kisspeptin-10, stimulate LH secretion, and an increase in LH plasma concentrations was observed after GnRH administration but not after kisspept-10 administration.
Luteal activity of Abadeh ecotype does in summer and winter and the effect of a single dose of kisspeptin-10 injection on luteinizing hormone secretion in the anestrus does
Mohammad Arjmand,Abdolah Mirzaei,Mohammad Reza Jafarzadeh Shirazi,Amin Tamadon,Mohammad Saied Salehi,M. Saeb,Mohammad Reza Namavar,Mohammad Reza Zandi,Hojatollah Shahheidari,Sara Moradi +9 more
TL;DR: Evaluating luteal activity in Abadeh ecotype goat during summer and winter and the effect of a single dose kisspeptin-10 injection on the secretion of luteinizing hormone (LH) in female anestrous goats found that in the absence of male goat in winter, some goats showed luteAL activity and others showed anestrus.
Journal ArticleDOI
Membrane and nuclear initiated estrogenic regulation of homeostasis.
TL;DR: The recent findings on the synaptic interactions between Kiss1, AgRP and POMC neurons are reviewed and how the rapid membrane-initiated and intracellular signaling cascades activated by E2 in these neurons are critical for control of homeostatic functions supporting reproduction are reviewed.
References
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Book
The Physiology of Reproduction
Ernst Knobil,J. D. Neill +1 more
TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
Journal ArticleDOI
Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system.
TL;DR: Comparing the distribution of the classical and novel forms of ER mRNA‐expressing neurons in the central nervous system (CNS) of the rat with in situ hybridization histochemistry provides evidence that the region‐specific expression of ER‐α, ER‐β, or both may be important in determining the physiological responses of neuronal populations to estrogen action.
Journal ArticleDOI
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
Journal ArticleDOI
Distribution of androgen and estrogen receptor mRNA‐containing cells in the rat brain: An in situ hybridization study
TL;DR: AR and ER may modulate nonolfactory sensory information as well since labeled cells were found in regions involved in the central relay of somatosensory information, including the mesencephalic nucleus of the trigeminal nerve, the ventral thalamic nuclear group, and the dorsal horn of the spinal cord.
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