Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Book ChapterDOI
Non‐alcoholic fatty liver disease
TL;DR: The most common cause of NASH is non-alcoholic fatty liver disease (NAFLD) and its potentially more severe subset nonsaltic steatohepatitis (NASH) as mentioned in this paper.
Journal ArticleDOI
Thrombocytopenia as a marker of liver steatosis in a low-endemic area for schistosomiasis mansoni
Alba Otoni,Carlos Antunes,Fernanda Ferreira Tavares,Débora Heloísa Quadros Araújo,Thiago A. Pereira,Leonardo Campos de Queiroz,Frederico Figueiredo Amâncio,José Roberto Lambertucci +7 more
TL;DR: Thrombocytopenia was not a good marker of hepatosplenic schistosomiasis mansoni in a low prevalence area in Brazil and Liver steatosis was associated with thrombocytes in this study.
Dissertation
Metabolic changes in non-alcoholic fatty liver disease : interactions with genes regulating fatty acid metabolism
TL;DR: This doctoral thesis demonstrated several alterations in fatty acid metabolism and endogenous desaturase activities that associate with NASH, independently of obesity and diet.
Journal ArticleDOI
Baseline homeostasis model assessment of insulin resistance associated with fibrosis progression in patients with nonalcoholic fatty liver disease without diabetes: A cohort study
Dae-Jeong Koo,Mi Yeon Lee,Inha Jung,Sun Joon Moon,Hyemi Kwon,Se Eun Park,Eun-Jung Rhee,Won Young Lee +7 more
TL;DR: In this article, the authors evaluated the association between baseline insulin resistance and future fibrosis progression in patients with nonalcoholic fatty liver disease (NAFLD) without diabetes, using homeostasis model assessment of insulin resistance (HOMA-IR).
Journal ArticleDOI
The Appropriate Opportunity for Evaluating Liver Fibrosis by Using the FIB-4 Index in Patients with Nonalcoholic Fatty Liver Disease in Japan
Yuya Seko,Kota Yano,Aya Takahashi,Shinya Okishio,Seita Kataoka,Keiichiroh Okuda,Atsushi Umemura,Kanji Yamaguchi,Michihisa Moriguchi,Saiyu Tanaka,Yoshito Itoh +10 more
TL;DR: To evaluate and predict advanced liver fibrosis with the FIB-4 index at a high cutoff point, the index should be used at 1 year after appropriate therapy, rather than at baseline, as is currently the case.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.