Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Journal ArticleDOI
A proposal from the Liver Forum for the management of comorbidities in nonalcoholic steatohepatitis therapeutic trials.
Raluca Pais,Bertrand Cariou,Mazen Noureddin,Sven Francque,Jörn M. Schattenberg,Manal F. Abdelmalek,Gadi Lalazar,Sharat Varma,Veronica Miller,Arun J. Sanyal,Vlad Ratziu +10 more
TL;DR: In this paper , the authors proposed guidance for the management of relevant comorbidities in both candidates and actual participants in NASH therapeutic trials, based on specific guidelines from scientific societies when available, but adapted them to the particulars of NASH trials with the optics of addressing multiple interacting requirements such as maintaining patient safety, reaching holistic therapeutic objectives, minimizing confounding effects on efficacy and safety of investigational agents and allowing trial completion.
Journal ArticleDOI
Transient elastography with controlled attenuation parameter (CAP) for diagnosis of moderate or severe steatosis in people with suspected non‐alcoholic fatty liver disease
Taisiia Turankova,Oleg Blyuss,Oleg Blyuss,Alexey I. Brazhnikov,Andrey A. Svistunov,Kurinchi Selvan Gurusamy,Kurinchi Selvan Gurusamy,Chavdar S Pavlov,Chavdar S Pavlov +8 more
TL;DR: Transient elastography with controlled attenuation parameter (CAP) for diagnosis of moderate or severe steatosis in people with suspected non-alcoholic fatty liver disease (Protocol)
Journal ArticleDOI
Incidence and Predictors of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease.
Shalimar,Sabreena Shafi Sheikh,Sagnik Biswas,Manas Vaishnav,Piyush Pathak,Aditya Pachisia,Himanshu Narang,Shubham Prasad,Shubham Mehta,Anugrah Dhooria,Shekhar Swaroop,Rithvik Golla,Ankit Agarwal,Ramesh Kumar Athi Kumar,Subrat K. Acharya +14 more
TL;DR: In this paper , the authors assessed the incidence and predictors of liver-related events (LREs) and mortality in NAFLD patients, and found that the mortality rate was higher in those with diabetes than those without diabetes.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.