Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Journal ArticleDOI
First-degree family history of diabetes is associated with nonalcoholic fatty liver disease independent of glucose metabolic status
TL;DR: In this article , the authors investigated the association between a first-degree family history of diabetes and NAFLD and the influence of glucose metabolic status on the risk of nonalcoholic fatty liver disease (NAFLD).
Acute Injury in Natural Diet-Induced Fatty Livers - A Model for Therapy Development
Huang Brian,A. E. Abbott Nicholas,Dacon Linai,McCormack Siobhan,Zhou Ping,Zhang Liming,Duan Bin,Li Jingsong,Zhang Bo,Yamin Michael,Paka Latha,D. Goldberg Itzhak,Narayan Prakash +12 more
Journal ArticleDOI
Progression of Nonalcoholic Fatty Liver Disease-Associated Fibrosis in a Large Cohort of Patients with Type 2 Diabetes
TL;DR: In this paper, a large-scale data on progression and regression of fibrosis in diabetics with nonalcoholic fatty liver disease (NAFLD) based on ICD-9 codes were identified.
Journal ArticleDOI
Validity of routine biochemical and ultrasound scores for prediction of hepatic fibrosis and steatosis in NAFLD
Rasha Eletreby,Zeinab Abdellatif,Yasmine Gaber,Ahmed M. Ramadan,Naglaa Ahmad,Hany Khattab,Mohamed Said,Yasmin Saad +7 more
TL;DR: In this article, the authors evaluated the validity of non-invasive scores and ultrasound findings to predict fibrosis and steatosis in a cohort of NAFLD patients who underwent liver biopsy.
Dissertation
The importance of fat and alcohol for progression and prognosis in chronic liver disease
TL;DR: It is found that a low to moderate consumption of alcohol is safe in PSC and possibly protective in NAFLD, and the strongest predictor of disease-specific mortality inNAFLD is the stage of fibrosis, which can have implications for the design of endpoints in future clinical studies.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.