Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Book ChapterDOI
Non-alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma
TL;DR: In this article , the authors proposed that altered metabolic state and its impact on immune response play an important role in the pathogenesis of NAFLD associated hepatocellular carcinoma (HCC) regardless of etiologies.
Posted ContentDOI
A Sequential Machine Learning Model for Identifying At-risk NASH by Combining Liver Stiffness Measurement and Protein Biomarkers
TL;DR: In this article , the authors compared the diagnostic accuracies of 13 protein biomarkers and developed a biomarker-based machine learning algorithm to predict at-risk non-alcoholic steatohepatitis (NASH) in patients with NAFLD.
Book ChapterDOI
Nonalcoholic Fatty Liver Disease: Clinical Features, Disease Modifiers, and Natural History
TL;DR: The clinical presentation and natural history of NAFLD as the hepatic manifestation of the metabolic syndrome as well as a variety of conditions such as cardiovascular disease and obstructive sleep apnea are addressed.
Journal ArticleDOI
Screening for NAFLD—Current Knowledge and Challenges
TL;DR: In this article , the authors summarise current knowledge and try to identify the limitations surrounding the screening policy for NAFLD in primary care, such as limitations in currently used non-invasive markers of fibrosis, cost-effectiveness and the absence of a licensed treatment.
Journal ArticleDOI
The effect of acute and chronic exercise on hepatic lipid composition
Scott A. Willis,Sundus Malaikah,Siôn A Parry,Stephen Bawden,Gaël Ennequin,Jack A. Sargeant,Thomas Yates,David R. Webb,Melanie J. Davies,David J. Stensel,Guruprasad P. Aithal,James A. King +11 more
TL;DR: In this paper , a review summarizes the acute (single bout) and chronic (exercise training) effects of exercise on hepatic lipid composition in rodents (acute studies, n = 3, chronic studies: n = 13) and humans (acitiative studies,n = 1, chronic study,n= 3) and concluded that an increased proportion of hepatic PUFA after acute and chronic exercise is the most consistent finding of this review.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.