Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Journal ArticleDOI
New paradigms in the histopathology of NAFLD
Andrew D. Clouston,Victoria L. Gadd,Katharine M. Irvine,Elizabeth E. Powell,Elizabeth E. Powell +4 more
TL;DR: There is increasing interest in the portal changes of NASH as these correlate with the progression of fibrosis, and disease-associated hepatocyte senescence appears to trigger an alternative regenerative pathway and the development of a periportal ductular reaction (DR), which may have a role in progressive fibrogenesis.
Log-Linear model and Multistate Model to Assess the Rate of Fibrosis in NAFLD Patients
TL;DR: The findings revealed that insulin resistance expressed by MOMA-IR 2 had the most deleterious effects among other factors for increasing the rate of forward progression of patients from state 1 to state 2 as well as from state 2 to state 3 and from state 3 to state 4.
Book ChapterDOI
Chapter 71 – Hepatic steatosis, steatohepatitis, and chemotherapy-related liver injury
Journal ArticleDOI
Hepatocellular carcinoma on the background of nonalcoholic fatty liver disease: epidemiological update
Elvire Desjonqueres,Elia Gigante +1 more
TL;DR: The main clinical and molecular features leading to the progression of liver disease and the development of HCC in non-alcoholic fatty liver disease in NAFLD are discussed and the emerging concept of metabolic associated fatty Liver disease and its association with the developed HCC are introduced.
Journal ArticleDOI
Usefulness of the SAF score to characterize NAFLD/NASH in non-cirrhotic HCV patients
Ahmed El Ray,Valérie Paradis,A. Y. Montasser,Maged El-Ghannam,Mohamed Shemis,Iris Nessim,Hoda Abu-Taleb,Tarik Asselah,Ashiq Mohamed,Nicolas Poté,Maha Akl,Patrick Marcellin +11 more
TL;DR: In this article , the SAF score (steatosis, activity, and fibrosis) has been developed for the assessment of the histological severity of non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.