Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Journal ArticleDOI
ABIDE: An Accurate Predictive Model of Liver Decompensation in Patients With Nonalcoholic Fatty Liver-Related Cirrhosis.
Luis Calzadilla-Bertot,Eduardo Vilar-Gomez,Eduardo Vilar-Gomez,Vincent Wai-Sun Wong,Manuel Romero-Gómez,Rocio Aller-de la Fuente,Grace Lai-Hung Wong,Marlen Castellanos,Mohammed Eslam,Archita P. Desai,Gary P. Jeffrey,Gary P. Jeffrey,Jacob George,Naga Chalasani,Leon A. Adams,Leon A. Adams +15 more
TL;DR: A model to predict hepatic decompensation in patients with NAFLD and cirrhosis is developed and validated and compared with currently available models.
Journal ArticleDOI
Multicenter Validation Study of a Diagnostic Algorithm to Detect NASH and Fibrosis in NAFLD Patients With Low NAFLD Fibrosis Score or Liver Stiffness.
Stephanie Liebig,Neele Stoeckmann,Andreas Geier,Monika Rau,Joern M Schattenberg,Matthias J. Bahr,Michael P. Manns,Elmar Jaeckel,Klaus Schulze-Osthoff,Heike Bantel +9 more
TL;DR: The combination of the M30 biomarker with NFS or TE enables a more reliable identification of patients with an increased risk of progressed NAFLD and improves patient stratification.
Journal ArticleDOI
Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study.
Susanna Lallukka,Sanja Sädevirta,Sanja Sädevirta,Markus T. Kallio,Markus T. Kallio,Panu K. Luukkonen,Panu K. Luukkonen,You Zhou,You Zhou,Antti Hakkarainen,Nina Lundbom,Marju Orho-Melander,Hannele Yki-Järvinen,Hannele Yki-Järvinen +13 more
TL;DR: Data show that liver fat is more important than the associated metabolic abnormalities as the predictor of future liver fat and fibrosis.
Journal ArticleDOI
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.
Henry R. Wilman,Constantinos A. Parisinos,Naeimeh Atabaki-Pasdar,Matt Kelly,E L Thomas,Stefan Neubauer,Anubha Mahajan,Aroon D. Hingorani,Riyaz S. Patel,Harry Hemingway,Paul W. Franks,Jimmy D. Bell,Rajarshi Banerjee,Hanieh Yaghootkar +13 more
TL;DR: In this paper, the authors used Mendelian randomisation to test the causal effects of 25 predominantly metabolic traits on liver iron content and found that higher central obesity plays a causal role in increased liver iron levels.
Journal ArticleDOI
Role of Insulin Resistance and Diabetes in the Pathogenesis and Treatment of Nonalcoholic Fatty Liver Disease
TL;DR: This review focuses on the mechanisms by which insulin resistance, and both lipo- and glucotoxicity, are believed to contribute to the development of NAFLD, and on the treatments tested in obese patients with T2DM and NAFLd, as a means to assist practitioners managing these complex patients.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.