Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Journal ArticleDOI
Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.
Anastasia-Stefania Alexopoulos,Anastasia-Stefania Alexopoulos,Matthew J Crowley,Matthew J Crowley,Ying Wang,Cynthia A. Moylan,Cynthia A. Moylan,Cynthia D. Guy,Ricardo Henao,Dawn Piercy,Keri A. Seymour,Ranjan Sudan,Dana Portenier,Anna Mae Diehl,Andrea D. Coviello,Manal F. Abdelmalek +15 more
TL;DR: In this article, the authors evaluated whether degree of glycemic control in the years preceding liver biopsy predicts the histological severity of NASH and found that moderate control was significantly associated with increased severity of ballooned hepatocytes, but not lobular inflammation.
Journal ArticleDOI
Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence
Guillermo Mazzolini,Jan-Peter Sowa,Catalina Atorrasagasti,Ö Kücükoglu,Wing-Kin Syn,Ali Canbay +5 more
TL;DR: An overview of the current evidence on the clinical significance of non-alcoholic fatty liver disease is provided and the molecular basis for NAFL development and progression is discussed.
Journal ArticleDOI
Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis
TL;DR: The currently available therapies for NASH including lifestyle, pharmacologic, and surgical options are discussed including diet, exercise, and pharmacotherapy.
Journal ArticleDOI
Natural History of Simple Steatosis or Nonalcoholic Fatty Liver.
Arka De,Ajay Duseja +1 more
TL;DR: Current concepts suggest the presence of a dynamic bidirectional cycling between NAFL and NASH with slow progression of fibrosis in majority of the patients, bringing into question the relevance of distinguishing NAFL from NASH.
Journal ArticleDOI
Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity.
Marco Arrese,Juan Pablo Arab,Francisco Barrera,Benedikt Kaufmann,Luca Valenti,Ariel E. Feldstein +5 more
TL;DR: In this paper, a review of existing data on the differential contribution of known factors to the pathogenesis and clinical expression of NAFLD, thus determining the different clinical subphenotypes observed in practice.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.