Journal ArticleDOI
A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
Raluca Pais,Frédéric Charlotte,Larissa Fedchuk,Pierre Bedossa,Pascal Lebray,Thierry Poynard,Vlad Ratziu +6 more
TLDR
A substantial proportion of patients with NAFL can progress towards well-defined NASH with bridging fibrosis, especially if metabolic risk factors deteriorate, and current monitoring practices of these patients should be revised.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01. It has received 417 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
Citations
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Journal ArticleDOI
Improvement in Non-alcoholic Fatty Liver Disease Score Correlates with Weight Loss in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: a Two-Centre Study from an Asian Cohort.
Zong Jie Koh,Hrishikesh Salgaonkar,Wei Jie Jonathan Lee,Guowei Kim,Chun Hai Tan,Anton Cheng,Davide Lomanto,Jimmy Bok Yan So,Yock Young Dan,Asim Shabbir +9 more
TL;DR: It is concluded that sleeve gastrectomy may be a viable treatment option for management of NAFLD in the obese using the NFS, a validated non-invasive scoring system used to assess advanced fibrosis.
Journal ArticleDOI
The Serum Creatinine Level Might Be Associated with the Onset of Impaired Fasting Glucose: A Community-based Longitudinal Cohort Health Checkup Study
Naohiko Yoshida,Teruki Miyake,Shin Yamamoto,Shinya Furukawa,Hidenori Senba,Sayaka Kanzaki,Mitsuhito Koizumi,Toru Ishihara,Osamu Yoshida,Masashi Hirooka,Teru Kumagi,Masanori Abe,Kohichiro Kitai,Bunzo Matsuura,Yoichi Hiasa +14 more
TL;DR: The fact that serum creatinine levels increase with exercise might demonstrate the importance of exercise therapy, and a low Creatinine level might be associated with the onset of IFG.
Journal ArticleDOI
Non-alcoholic fatty liver disease
Michael Pavlides,Jeremy Cobbold +1 more
TL;DR: A 58-year-old man was seen by his general practitioner; after a routine health check, he demonstrated elevated liver biochemistry, with an alanine aminotransferase (ALT) value of 45 IU/L.
Journal ArticleDOI
Hepatocellular Carcinoma Due to Nonalcoholic Fatty Liver Disease: Current Concepts and Future Challenges
TL;DR: In this article , the authors described the pathophysiology of NAFLD and NASH, risk factors associated with disease progression, related complications, and mortality, and concluded the clinical evidence for treating fibrosis and preventing hepatocellular carcinoma (HCC) in those at risk with nonalcoholic fatty liver disease-associated HCC.
Journal ArticleDOI
Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects.
Javier Ampuero,Javier Ampuero,Rocío Aller,Rocío Gallego-Durán,Javier Crespo,Javier Abad,Águeda González-Rodríguez,Judith Gómez-Camarero,Joan Caballería,Oreste Lo Iacono,Luis Ibañez,Javier García-Samaniego,Rosa Martin-Mateos,Rubén Francés,Conrado M. Fernández-Rodríguez,Moisés Diago,Germán Soriano,Raúl J. Andrade,Raquel Latorre,Francisco Jorquera,Rosa Maria Morillas,Desam Escudero,Pamela Estévez,Manuel Hernández-Guerra,Salvador Augustin,María Jesús Pareja‐Megia,Jesus M. Banales,Patricia Aspichueta,Salvador Benlloch,José Miguel Rosales,Javier Salmerón,Juan Turnes,Manuel Romero-Gómez,Manuel Romero-Gómez,HEPAmet Registry +34 more
TL;DR: In this paper, the authors assessed the NASH distribution and its components across the fibrosis stages and their impact on the prognosis and their relationship with the concept of metabolic-associated fatty liver disease (MAFLD).
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Leon A. Adams,James F. Lymp,Jenny St. Sauver,Schuyler O. Sanderson,Keith D. Lindor,Ariel E. Feldstein,Paul Angulo +6 more
TL;DR: Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Journal ArticleDOI
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
Giulio Marchesini,Elisabetta Bugianesi,Gabriele Forlani,Fernanda Cerrelli,Marco Lenzi,R. Manini,S. Natale,Ester Vanni,Nicola Villanova,Nazario Melchionda,Mario Rizzetto +10 more
TL;DR: The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.