Acute and chronic arsenic toxicity
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TLDR
There are no evidence based treatment regimens to treat chronic arsenic poisoning but antioxidants have been advocated, though benefit is not proven, and there is increasing emphasis on using alternative supplies of water.Abstract:
Arsenic toxicity is a global health problem affecting many millions of people. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Arsenic is present as a contaminant in many traditional remedies. Arsenic trioxide is now used to treat acute promyelocytic leukaemia. Absorption occurs predominantly from ingestion from the small intestine, though minimal absorption occurs from skin contact and inhalation. Arsenic exerts its toxicity by inactivating up to 200 enzymes, especially those involved in cellular energy pathways and DNA synthesis and repair. Acute arsenic poisoning is associated initially with nausea, vomiting, abdominal pain, and severe diarrhoea. Encephalopathy and peripheral neuropathy are reported. Chronic arsenic toxicity results in multisystem disease. Arsenic is a well documented human carcinogen affecting numerous organs. There are no evidence based treatment regimens to treat chronic arsenic poisoning but antioxidants have been advocated, though benefit is not proven. The focus of management is to reduce arsenic ingestion from drinking water and there is increasing emphasis on using alternative supplies of water.read more
Citations
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Journal ArticleDOI
Arsenic trioxide and neuroblastoma cytotoxicity
TL;DR: Arsenic trioxide has the capacity to kill multidrug-resistant neuro-blastoma cells in vitro and in vivo and the drug is currently being evaluated in clinical trials.
Journal ArticleDOI
Heavy metal bioaccumulation in different fish species in the coast of the Persian Gulf, Iran
TL;DR: In this paper, a study project aimed to determine the concentrations of five heavy metals (Al, As, Cd, Hg and Pb) in different fish species in the coast of the Persian Gulf in Iran.
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A case of Bowen's disease and small-cell lung carcinoma: long-term consequences of chronic arsenic exposure in Chinese traditional medicine.
Linda Lee,Gwyn Bebb +1 more
TL;DR: The temporal association with Bowen’s disease in the absence of other chemical or occupational exposure strongly points to a causal role for arsenic in this case of small-cell lung cancer.
Journal ArticleDOI
Biological effects of inorganic arsenic on primary cultures of rat astrocytes
Irene Catanzaro,Gabriella Schiera,Giulia Sciandrello,Giusi Barbata,Fabio Caradonna,Patrizia Proia,Italia Di Liegro +6 more
TL;DR: The effects of arsenite (NaAsO2) on primary cultures of rat astrocytes is reported and an anti-PIPPin antibody-positive faster migrating protein appears, the concentration of which was recently reported to change in response to stress induced by cadmium.
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Protective effect of Emblica-officinalis in arsenic induced biochemical alteration and inflammation in mice.
Manish Kumar Singh,Suraj Singh Yadav,Rajesh Singh Yadav,Abhishek Chauhan,Devendra Kumar Katiyar,Sanjay Khattri +5 more
TL;DR: Results of the present study clearly indicate that arsenic induced immunotoxicity linked with inflammation has been significantly protected through simultaneous treatment with arsenic and amla that was due to anti-inflammatory and antioxidant activity of amla.
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