AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization
Anja Bastian,Satoshi Matsuzaki,Kenneth M. Humphries,Gavin Pharaoh,Arpit Doshi,Nilesh Zaware,Aleem Gangjee,Michael A. Ihnat,Michael A. Ihnat +8 more
TLDR
Results suggest that AG311 at least partially mediates its antitumor effect through inhibition of complex I, which could be exploited in its use as an anticancer agent.About:
This article is published in Cancer Letters.The article was published on 2017-03-01 and is currently open access. It has received 35 citations till now. The article focuses on the topics: Oxygen tension & Pyruvate dehydrogenase kinase.read more
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Targeting Metabolism for Cancer Therapy
TL;DR: Current understanding of cancer metabolism is reviewed and how this might guide treatments targeting the metabolic requirements of tumor cells are discussed.
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
Richard Possemato,Franziska K. Lorbeer,Erol C. Bayraktar,Prathapan Thiru,Burcu Yucel,Timothy C. Wang,Walter W. Chen,Clary B. Clish,David M. Sabatini,Kıvanç Birsoy +9 more
TL;DR: A continuous-flow culture apparatus for maintaining proliferating cells in low-nutrient media for long periods of time is developed and used to undertake competitive proliferation assays, concluding that mtDNA mutations and impaired glucose utilization are potential biomarkers for identifying tumours with increased sensitivity to OXPHOS inhibitors.
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Metabolic Reprogramming in Triple-Negative Breast Cancer
Xiangyu Sun,Mozhi Wang,Mengshen Wang,Xueting Yu,Jingyi Guo,Tie Sun,Xinyan Li,Litong Yao,Haoran Dong,Ying-Ying Xu +9 more
TL;DR: How triple-negative breast cancer cells reprogram their metabolic phenotype and that of stromal cells in the microenvironment to survive under nutrient-poor conditions is discussed and the role of metabolic adaption in mediating metastasis and chemoresistance of triple- negative breast cancer tumors is focused on.
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The Mitochondrial Complex(I)ty of Cancer.
TL;DR: The role of complex I in tumorigenesis is discussed, focusing on the specific participation of Complex I subunits in proliferation and metastasis of cancer cells.
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Iron metabolism and its contribution to cancer (Review)
TL;DR: Previous studies on the physiology of iron metabolism and its role in cancer are summarized and the significance of iron regulation, and the association between iron homeostasis and carcinogenic mechanisms are discussed.
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
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Why do cancers have high aerobic glycolysis
TL;DR: In this article, the authors propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions, which leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity.
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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
TL;DR: This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination studies, in terms of experimental design, data acquisition, data interpretation, and computerized simulation.
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Otto Warburg's contributions to current concepts of cancer metabolism
TL;DR: Otto Warburg's observations are re-examine in relation to the current concepts of cancer metabolism as being intimately linked to alterations of mitochondrial DNA, oncogenes and tumour suppressors, and thus readily exploitable for cancer therapy.
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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
TL;DR: It is concluded that the drug's pharmacological effects are mediated, at least in part, through a time-dependent, self-limiting inhibition of the respiratory chain that restrains hepatic gluconeogenesis while increasing glucose utilization in peripheral tissues.