All MSCs are pericytes
TLDR
A subpopulation of human perivascular cells that express both pericyte and mesenchymal stem cell (MSC) markers in situ is document, establishing that MSCs found throughout fetal and adult tissues are members of thepericyte family of cells.About:
This article is published in Cell Stem Cell.The article was published on 2008-09-11 and is currently open access. It has received 647 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Adult stem cell.read more
Citations
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Satellite Cells and the Muscle Stem Cell Niche
TL;DR: For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.
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The MSC: An Injury Drugstore
Arnold I. Caplan,Diego Correa +1 more
TL;DR: Evidence that leads to the proposal that during local injury, MSCs are released from their perivascular location, become activated, and establish a regenerative microenvironment by secreting bioactive molecules and regulating the local immune response is discussed.
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Why are MSCs therapeutic? New data: new insight
TL;DR: A new, enlightened era of experimentation and clinical trials has been initiated with xenogenic and allogeneic MSCs.
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The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
Paolo Bianco,Xu Cao,Paul S. Frenette,Jeremy J. Mao,Pamela Gehron Robey,Paul J. Simmons,Cun-Yu Wang +6 more
TL;DR: Significant ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs, which have a major impact on their envisioned therapeutic use.
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Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine
TL;DR: Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state.
References
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
TL;DR: Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.
TL;DR: The biological basis for the in vivo functioning of MSCs through development and aging is summarized and they appear to be valuable mediators for tissue repair and regeneration.
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In search of the in vivo identity of mesenchymal stem cells
TL;DR: This model proposes that MSCs stabilize blood vessels and contribute to tissue and immune system homeostasis under physiological conditions and assume a more active role in the repair of focal tissue injury and provides a basis for the rational design of additional in vivo therapeutic approaches.
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Pericytes in the microvasculature
TL;DR: Observations indicate that the primordial endothelium can recruit undifferentiated mesenchymal cells and direct their differentiation into pericytes in microvessels, and smooth muscle cells in large vessels.
Related Papers (5)
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more