An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
Shannon M. Reilly,Shian Huey Chiang,Shian Huey Chiang,Stuart J. Decker,Louise Chang,Maeran Uhm,Martha J. Larsen,John R. Rubin,Jonathan Mowers,Nicole M. White,Irit Hochberg,Irit Hochberg,Michael Downes,Ruth T. Yu,Christopher Liddle,Christopher Liddle,Ronald M. Evans,Ronald M. Evans,Da Young Oh,Pingping Li,Jerrold M. Olefsky,Alan R. Saltiel +21 more
TLDR
The authors showed that amlexanox, currently used to treat asthma and canker sores, is a relatively specific inhibitor of the noncanonical IκB kinases IKK-α and TANK-binding kinase 1 (TBK1) and that it improves metabolic disease in mouse genetic and dietary models of obesity.Abstract:
Alan Saltiel and his colleagues report that the approved drug amlexanox, currently used to treat asthma and canker sores, is a relatively specific inhibitor of the noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) and that it improves metabolic disease in mouse genetic and dietary models of obesity. These results suggest this drug may be repurposed to treat obesity and insulin resistance.read more
Citations
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Mechanisms of Insulin Action and Insulin Resistance
TL;DR: This work aims to develop an integrated physiological perspective, placing the intricate signaling effectors that carry out the cell-autonomous response to insulin in the context of the tissue-specific functions that generate the coordinated organismal response.
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Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management
Arun Chaudhury,Chitharanjan Duvoor,Vijaya Sena Reddy Dendi,Shashank Kraleti,Aditya Chada,Rahul Ravilla,Asween Marco,Nawal Singh Shekhawat,Maria Theresa E. Montales,Kevin Kuriakose,Appalanaidu Sasapu,Alexandria Beebe,Naveen Patil,Chaitanya K. Musham,Govinda Prasad Lohani,Wasique Mirza +15 more
TL;DR: In this mini review, the current management principles, including the spectrum of medications that are currently used for pharmacologic management, for lowering the elevated blood glucose in T2DM are outlined.
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TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
Bart Everts,Eyal Amiel,Stanley Ching-Cheng Huang,Amber M. Smith,Chih-Hao Chang,Wing Y. Lam,Veronika Redmann,Tori C. Freitas,Julianna Blagih,Gerritje J.W. van der Windt,Maxim N. Artyomov,Russell G. Jones,Erika L. Pearce,Edward J. Pearce +13 more
TL;DR: The rapid induction of glycolytic flux increased within minutes of exposure to TLR agonists and served an essential role in supporting the de novo synthesis of fatty acids for the expansion of the endoplasmic reticulum and Golgi required for the production and secretion of proteins that are integral to DC activation.
Journal ArticleDOI
Adapting to obesity with adipose tissue inflammation.
TL;DR: The connection between adipose tissue inflammation and the development of insulin resistance and catecholamine resistance is examined and the ensuing state of metabolic inflexibility is discussed.
Journal ArticleDOI
Brown and Beige Fat: Physiological Roles beyond Heat Generation.
TL;DR: This work aims to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes.
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