An update on the biology of sphingosine 1-phosphate receptors.
Victoria A. Blaho,Timothy Hla +1 more
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TLDR
This review will focus on the most recent advances in S1PRs, as they become attractive therapeutic targets in several diseases, such as chronic inflammatory pathologies, autoimmunity, and cancer.About:
This article is published in Journal of Lipid Research.The article was published on 2014-08-01 and is currently open access. It has received 399 citations till now. The article focuses on the topics: Sphingosine-1-phosphate & Sphingosine.read more
Citations
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Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Richard L. Proia,Timothy Hla +1 more
TL;DR: The availability of pharmacological tools as well as mouse genetic models has revealed several physiological actions of S1P and begun to shed light on its pathological roles, providing novel opportunities for therapeutic intervention with possibilities to target not only GPCRs but also transporters, metabolic enzymes, and chaperones.
Journal ArticleDOI
HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation
Sylvain Galvani,Marie Sanson,Victoria A. Blaho,Steven L. Swendeman,Hideru Obinata,Heather Conger,Björn Dahlbäck,Mari Kono,Richard L. Proia,Jonathan D. Smith,Timothy Hla +10 more
TL;DR: The ability of ApoM+HDL to act as a biased agonist on S1P1 inhibits vascular inflammation, which may partially explain the cardiovascular protective functions of HDL.
Journal ArticleDOI
Inflammation, vitamin B6 and related pathways.
TL;DR: The active form of vitamin B6, pyridoxal 5'-phosphate (PLP), serves as a co-factor in more than 150 enzymatic reactions, and is inversely associated with numerous inflammatory markers in clinical and population-based studies.
Journal ArticleDOI
Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances
TL;DR: Recent advances in the area in relation to receptor-mediated signalling by S1P and novel intracellular targets of this lipid are summarized.
Journal ArticleDOI
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency
Svjetlana Lovric,Sara Gonçalves,Sara Gonçalves,Heon Yung Gee,Babak Oskouian,Honnappa Srinivas,Won-Il Choi,Shirlee Shril,Shazia Ashraf,Weizhen Tan,Jia Rao,Merlin Airik,David Schapiro,Daniela A. Braun,Carolin E. Sadowski,Eugen Widmeier,Eugen Widmeier,Tilman Jobst-Schwan,Johanna Magdalena Schmidt,Vladimir Girik,Guido Capitani,Jung H. Suh,Noelle Lachaussée,Noelle Lachaussée,Christelle Arrondel,Christelle Arrondel,Julie Patat,Julie Patat,Olivier Gribouval,Olivier Gribouval,Monica Furlano,Monica Furlano,Monica Furlano,Olivia Boyer,Olivia Boyer,Alain Schmitt,Alain Schmitt,Vincent Vuiblet,Seema Hashmi,Rainer Wilcken,Francois P. Bernier,A. Micheil Innes,Jillian S. Parboosingh,Ryan E. Lamont,Julian P. Midgley,Nicola A.M. Wright,Jacek Majewski,Martin Zenker,Franz Schaefer,Navina Kuss,Johann Greil,Thomas Giese,Klaus Schwarz,Vilain Catheline,Denny Schanze,Ingolf Franke,Yves Sznajer,Anne-Sophie Truant,Brigitte Adams,Julie Désir,Ronald Biemann,York Pei,Elisabet Ars,Nuria Lloberas,A. Madrid,Vikas R. Dharnidharka,Anne M Connolly,Marcia C. Willing,Megan A. Cooper,Richard P. Lifton,Richard P. Lifton,Matias Simons,Matias Simons,Howard Riezman,Corinne Antignac,Corinne Antignac,Julie D. Saba,Friedhelm Hildebrandt +77 more
TL;DR: Results indicate that SGPL1 mutations cause a syndromic form of Steroid-resistant nephrotic syndrome, which causes chronic kidney disease cases in patients with SRNS.
References
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