Animal Models Utilized for the Development of Influenza Virus Vaccines.
Reads0
Chats0
TLDR
In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
Citations
More filters
Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
More filters
Journal ArticleDOI
Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future
TL;DR: Nonhuman primate models of respiratory diseases will continue to be instrumental for translating biomedical research for improvement of human health, and studies defining the influence of inhaled microbes, pollutants, or allergens on the nonhuman primates lung have provided insight on disease pathogenesis.
Journal ArticleDOI
Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model.
Wen-Chun Liu,Raffael Nachbagauer,Daniel Stadlbauer,Alicia Solórzano,Francesco Berlanda-Scorza,Adolfo García-Sastre,Peter Palese,Florian Krammer,Randy A. Albrecht +8 more
TL;DR: The findings from this preclinical study suggest that an LAIV-LAIV vaccination regimen would be more efficient in providing broadly protective immunity against influenza virus infection as compared to other approaches tested here.
Journal ArticleDOI
The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.
TL;DR: The disease burden for acute respiratory viral infections for which current conventional development strategies have failed to produce therapeutics that meet clinical need is described and its utility to assist in the development of novel diagnostics is described.
Journal ArticleDOI
Evidence of a cross-protective immune response to influenza A in the cotton rat model.
TL;DR: Cross-protection from heterosubtypic influenza A challenge in cotton rats was characterized by enhanced viral clearance, protection from tachypnea, a vigorous early cellular recall response, and a reduction in bronchiolar epithelial cell damage.
Journal ArticleDOI
Moving Forward: Recent Developments for the Ferret Biomedical Research Model.
Randy A. Albrecht,Wen-Chun Liu,Andrea J. Sant,S. Mark Tompkins,Andrew Pekosz,Victoria A. Meliopoulos,Sean Cherry,Paul G. Thomas,Stacey Schultz-Cherry +8 more
TL;DR: Important recent advances that will accelerate biomedical research with this animal model that is widely recognized for its utility in influenza virus research are described.