Animal Models Utilized for the Development of Influenza Virus Vaccines.
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In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
Introductions and Evolution of Human-Origin Seasonal Influenza A Viruses in Multinational Swine Populations
Martha I. Nelson,David E. Wentworth,Marie R. Culhane,Amy L. Vincent,Cécile Viboud,Matthew P. LaPointe,Xudong Lin,Edward C. Holmes,Susan E. Detmer +8 more
TL;DR: Through a large-scale sequencing effort, a novel influenza virus of wholly human origin is identified that has been circulating undetected in swine for at least 7 years and it is demonstrated that human-to-swine transmission has occurred frequently on a global scale over the past decades but that there is little persistence of human virus internal gene segments inSwine.
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Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine.
E. Bridie Clemens,Carolien E. van de Sandt,Sook San Wong,Linda M. Wakim,Sophie A. Valkenburg +4 more
TL;DR: This review aims to bring together basic fundamentals of T cell biology with human clinical data, which need to be considered for the implementation of a universal vaccine against influenza that harnesses the power of T cells.
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Protective effect of vaccination against induced influenza a.
TL;DR: The vaccine represented the allantoic fluid of fertile hen's eggs infected 48 hours previously with either the PR8 strain of influenza virus, Type A, or the Lee strain, Type B, and was concentrated by the procedure of Francis and Salk,1 inactivated with formalin 1:2000, and bottled and tested for sterility by the approved procedures for biological products.
Journal ArticleDOI
Recurring influenza B virus infections in seals.
Rogier Bodewes,Danny Morick,Gerrie de Mutsert,Nynke Osinga,Theo M. Bestebroer,Stefan van der Vliet,Saskia L. Smits,Thijs Kuiken,Guus F. Rimmelzwaan,Ron A. M. Fouchier,Albert D. M. E. Osterhaus +10 more
TL;DR: 9 juvenile seals must have become infected from late 2009 through early 2010 to suggest that the infection was caused by the novel introduction of an influenza B virus in seals in the coastal waters of the Netherlands, either by seals or by another source.
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High infectivity and pathogenicity of influenza A virus via aerosol and droplet transmission
TL;DR: Establishing a dose response model for influenza provides a firm basis for studies of interventions reducing exposure to different classes of infectious particles, and demonstrates that with these dose response models the probabilities of infection by either aerosol or sedimenting droplets are approximately equal.