Animal Models Utilized for the Development of Influenza Virus Vaccines.
TLDR
In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
Norbert Pardi,Kaela Parkhouse,Ericka Kirkpatrick,Meagan McMahon,Seth J. Zost,Barbara L. Mui,Ying K. Tam,Katalin Karikó,Christopher Barbosa,Thomas D. Madden,Michael J. Hope,Florian Krammer,Scott E. Hensley,Drew Weissman +13 more
TL;DR: It is shown that immunization with nucleoside-modified and purified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and protects from heterosubtypic virus infection.
Journal ArticleDOI
Influenza Virus Reservoirs and Intermediate Hosts: Dogs, Horses, and New Possibilities for Influenza Virus Exposure of Humans
TL;DR: What is known about the role of intermediate hosts in influenza emergence is outlined, knowledge of the new canine influenza viruses (CIVs) and how they provide key new information on the process of host adaptation is summarized, and the risk these viruses pose to human populations is assessed.
Journal ArticleDOI
A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice
Alec W. Freyn,Jamile Ramos da Silva,Jamile Ramos da Silva,Victoria C. Rosado,Carly M. Bliss,Matthew Pine,Barbara L. Mui,Ying K. Tam,Thomas D. Madden,Luís Carlos de Souza Ferreira,Drew Weissman,Florian Krammer,Lynda Coughlan,Peter Palese,Norbert Pardi,Raffael Nachbagauer +15 more
TL;DR: The immunity conferred by nucleoside-modified mRNA-lipid nanoparticle vaccines provided protection from challenge with pandemic H1N1 virus at 500 times the median lethal dose after administration of a single immunization, and the combination vaccine protected from morbidity at a dose of 50 ng per antigen.
Journal ArticleDOI
Adeno-associated virus–targeted disruption of the CFTR gene in cloned ferrets
Xingshen Sun,Ziying Yan,Yaling Yi,Ziyi Li,Diana Lei,Christopher S. Rogers,Juan Chen,Yulong Zhang,Michael J. Welsh,Gregory H. Leno,John F. Engelhardt +10 more
TL;DR: This study describes the production of a CFTR gene-deficient model in the domestic ferret using recombinant adeno-associated virus-mediated gene targeting in fibroblasts, followed by nuclear transfer cloning.
Journal ArticleDOI
Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses
Donald M. Carter,Christopher A. Darby,Bradford C. Lefoley,Corey J. Crevar,Timothy Alefantis,Raymond P. Oomen,Stephen Anderson,Tod Strugnell,Guadalupe Cortes-Garcia,Thorsten U. Vogel,Mark Parrington,Harold Kleanthous,Ted M. Ross +12 more
TL;DR: This is the first report describing a COBRA-based HA vaccine strategy that elicits a universal, broadly reactive, protective response against seasonal and pandemic H1N1 isolates.