Animal Models Utilized for the Development of Influenza Virus Vaccines.
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In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
The Mouse Model for Influenza
TL;DR: Although Ferrets are exquisitely susceptible to infection with human influenza viruses, hamsters, guinea pigs, cotton rats, and rats have also been used for influenza research.
Journal ArticleDOI
Potential role of human challenge studies for investigation of influenza transmission
Ben Killingley,Joanne E. Enstone,Robert Booy,Andrew Hayward,John S. Oxford,Neil M. Ferguson,Jonathan S Nguyen Van-Tam +6 more
TL;DR: The latest intervention studies in human challenge studies with influenza virus are reviewed and the potential of challenge studies to address the remaining gaps in knowledge are discussed.
Journal ArticleDOI
Seasonal influenza vaccine in immunocompromised persons.
Mohammad Bosaeed,Deepali Kumar +1 more
TL;DR: The impact of influenza infection and evidence for vaccine effectiveness and immunogenicity are discussed, with a focus on immunocompromised persons and those with solid organ transplants and autoimmune conditions receiving biologic therapies.
Journal ArticleDOI
Early host responses of seasonal and pandemic influenza A viruses in primary well-differentiated human lung epithelial cells.
TL;DR: This study hypothesized that host responses during infection of well-differentiated, primary human bronchial epithelial cells (wd-NHBE) may differ between seasonal and fatal H1N1pdm isolates from a fatal and nonfatal case, and revealed differences in temporal dynamics and basal levels of cytokine/chemokine responses of wd- NHBE cells infected with each isolate.
Journal ArticleDOI
Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection.
Kiyoko Iwatsuki-Horimoto,Noriko Nakajima,Yurie Ichiko,Yuko Sakai-Tagawa,Takeshi Noda,Hideki Hasegawa,Yoshihiro Kawaoka +6 more
TL;DR: Hamsters have the potential to be a small-animal model for the study of influenza virus infection, including studies of the pathogenicity of H3N2 viruses and other strains, as well as for use in H1N1 virus transmission studies.