Animal Models Utilized for the Development of Influenza Virus Vaccines.
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In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
Of mice and men: the host response to influenza virus infection.
Heike Kollmus,Carolin Pilzner,Sarah R. Leist,Mark T. Heise,Robert Geffers,Klaus Schughart,Klaus Schughart +6 more
TL;DR: A cross-species gene expression study of the peripheral blood from human patients and from the highly genetically diverse Collaborative Cross mouse population after IV infection demonstrates that changes of gene expression in individual genes are highly similar in mice and humans.
Journal ArticleDOI
Pregnancy preserves pulmonary function following influenza virus infection in C57BL/6 mice.
Meghan S. Vermillion,Andrew Nelson,Landon G. vom Steeg,Jeffrey Loube,Wayne Mitzner,Sabra L. Klein +5 more
TL;DR: The data suggest that pregnancy in mice is associated with significant alterations in pulmonary physiology but that these changes served to preserve lung function during IAV infection, and may serve to protect females during severe influenza.
Journal ArticleDOI
Meeting report: Convening on the influenza human viral challenge model for universal influenza vaccines, Part 1: Value; challenge virus selection; regulatory, industry and ethical considerations; increasing standardization, access and capacity.
Bruce L. Innis,Francesco Berlanda Scorza,Jeremy S. Blum,Varsha K. Jain,Anastazia Older Aguilar,Diane J. Post,Paul C. Roberts,Niteen Wairagkar,Janet White,Joseph S. Bresee +9 more
TL;DR: Experts agreed that a research network of institutions working with a standardized CHIVIM could contribute important data to support more rapid development and licensure of novel vaccines capable of providing long-lasting protection against seasonal and pandemic influenza strains.
Journal ArticleDOI
The Microminipig as an Animal Model for Influenza A Virus Infection
Kiyoko Iwatsuki-Horimoto,Noriko Nakajima,Masatoshi Shibata,Kenta Takahashi,Yuko Sato,Maki Kiso,Seiya Yamayoshi,Mutsumi Ito,Satoko Enya,Masayoshi Otake,Akihisa Kangawa,Tiago J. S. Lopes,Hirotaka Ito,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +15 more
TL;DR: The distribution of influenza virus receptors in the respiratory tract of the microminipig was similar to that of the pig, and the sensitivity of micromInipigs to influenza A viruses was the same as that of miniature pigs, suggesting that microm inipigs represent a novel animal model for influenza A virus infection.
Journal ArticleDOI
Host-Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model.
Elizabeth A. Pharo,Sinéad M. Williams,Victoria Boyd,Vinod Sundaramoorthy,Peter A. Durr,Michelle L. Baker +5 more
TL;DR: For example, in this paper, NHBE cells were differentiated under air-liquid interface (ALI) conditions to form an in vitro pseudostratified epithelium and the responses of well-differentiated (wdNHBE) cells were examined following infection with the 2009 pandemic Influenza A/H1N1pdm09 strain or following challenge with the dsRNA mimic, poly(I:C).