Animal Models Utilized for the Development of Influenza Virus Vaccines.
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In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
Preclinical Evaluation of a Replication-Deficient Intranasal ΔNS1 H5N1 Influenza Vaccine
Julia Romanova,Brigitte M. Krenn,Markus Wolschek,Boris Ferko,Ekaterina Romanovskaja-Romanko,Alexander Morokutti,Anna-Polina Shurygina,Sabine Nakowitsch,Tanja Ruthsatz,Bettina Kiefmann,Ulrich König,Michael Bergmann,Monika Sachet,Shobana Balasingam,Alex Mann,John S. Oxford,Martin Slais,Oleg I. Kiselev,Thomas Muster,Andrej Egorov +19 more
TL;DR: These findings show that intranasal immunization with the replication deficient H5N1 ΔNS1 vaccine candidate is sufficient to induce a protective immune response against H 5N1 viruses.
Journal ArticleDOI
Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model.
Megan E. Ermler,Ericka Kirkpatrick,Weina Sun,Rong Hai,Fatima Amanat,Veronika Chromikova,Peter Palese,Florian Krammer +7 more
TL;DR: Results from serum transfer experiments and antibody-dependent cell-mediated cytotoxicity assays indicate that this protection is antibody mediated and based on Fc effector functions, suggesting that chimeric hemagglutinin-based vaccination is a viable strategy to broadly protect against influenza B virus infection.
Journal ArticleDOI
An overview of the regulation of influenza vaccines in the United States.
Jerry P. Weir,Marion Gruber +1 more
TL;DR: This review describes the process of licensing influenza vaccines in the U.S., the process and steps involved in the annual updating of seasonal influenza vaccines, and some recent experiences and regulatory challenges faced in development and evaluation of novel influenza vaccines.
Journal ArticleDOI
Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection
Hannah C. Watkins,C. Garrett Rappazzo,Jaclyn S. Higgins,Xiangjie Sun,Nicole Brock,Annie Chau,Aditya Misra,Joseph P.B. Cannizzo,Michael R. King,Taronna R. Maines,Cynthia A. Leifer,Gary R. Whittaker,Matthew P. DeLisa,David Putnam +13 more
TL;DR: It is reported that rOMVs derived from this lipid IVa strain have substantially attenuated pyrogenicity yet retain high levels of immunogenicity, promote dendritic cell maturation, and generate a balanced Th1/Th2 humoral response.
Journal ArticleDOI
Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets
Raffael Nachbagauer,Matthew S. Miller,Rong Hai,Alex B. Ryder,John K. Rose,Peter Palese,Adolfo García-Sastre,Florian Krammer,Randy A. Albrecht +8 more
TL;DR: Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.