Animal Models Utilized for the Development of Influenza Virus Vaccines.
TLDR
In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
Cloning, expression and immunoassay detection of ferret IFN-γ
Atsuo Ochi,Ali Danesh,Ali Danesh,Charit Seneviratne,David Banner,Mark E. DeVries,Thomas Rowe,Luoling Xu,Longsi Ran,Markus Czub,Steven E. Bosinger,Mark J. Cameron,Cheryl M. Cameron,David J. Kelvin,David J. Kelvin,David J. Kelvin +15 more
TL;DR: The cloning of the full-length cDNA for ferret IFN-γ is described and multiple sequence alignment of the predicted amino acid sequence with those of other species indicates that the predicted ferret protein shares the highest identity with Eurasian badger IFn-γ.
Journal ArticleDOI
Adaption of Seasonal H1N1 Influenza Virus in Mice
Lili Xu,Linlin Bao,Fengdi Li,Qi Lv,Yila Ma,Jiangfang Zhou,Yanfeng Xu,Wei Deng,Lingjun Zhan,Hua Zhu,Chunmei Ma,Yuelong Shu,Chuan Qin +12 more
TL;DR: Mouse adaption of human influenza A virus may change the ability to replicate in mouse lungs, which induces strong immune responses and inflammation in mice, and may provide new insights into understanding the mechanisms underlying the mouse ada adaptation and pathogenicity of highly virulent influenza viruses.
Journal ArticleDOI
Origins of the 1918 Pandemic: Revisiting the Swine "Mixing Vessel" Hypothesis.
Martha I. Nelson,Michael Worobey +1 more
TL;DR: There is no empirical evidence that swine played a role in the emergence of human influenza in 1918, 1957, or 1968, and swine are not necessary to mediate the establishment of avian viruses in humans, which invites new perspectives on the evolutionary processes underlying pandemic emergence.
Journal ArticleDOI
Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques.
Yasushi Itoh,Hiroichi Ozaki,Hirohito Ishigaki,Yoshihiro Sakoda,Tomoya Nagata,Kosuke Soda,Norikazu Isoda,Taichiro Miyake,Hideaki Ishida,Kiyoko Okamoto,Misako Nakayama,Hideaki Tsuchiya,Ryuzo Torii,Hiroshi Kida,Kazumasa Ogasawara +14 more
TL;DR: It is demonstrated that this H7N7 HPAIV strain is pathogenic to macaque and that the vaccine conferred protective immunity to macaques against H7n7 H PAIV infection.
Journal ArticleDOI
Quantitative relationships between the immunizing dose of epidemic influenza virus and the resultant immunity
TL;DR: A direct proportion exists between the concentration of epidemic influenza virus used for intraperitoneal immunization of mice and the degree of immunity to intranasal infection which develops, and the level of immunity of ferrets in a state of partial immunity induced as a result of subcutaneous vaccination with active influenza virus.