Animal Models Utilized for the Development of Influenza Virus Vaccines.
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In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
Quadrivalent influenza nanoparticle vaccines induce broad protection.
Seyhan Boyoglu-Barnum,Daniel Ellis,Rebecca A. Gillespie,Geoffrey B. Hutchinson,Young-Jun Park,Syed M. Moin,Oliver J. Acton,Oliver J. Acton,Rashmi Ravichandran,Michael E. P. Murphy,Deleah Pettie,Nick Matheson,Lauren Carter,Adrian Creanga,Michael J. Watson,Sally Kephart,Sila Ataca,John R. Vaile,George Ueda,Michelle C. Crank,Lance Stewart,Kelly K. Lee,Miklos Guttman,David Baker,John R. Mascola,David Veesler,Barney S. Graham,Neil P. King,Masaru Kanekiyo +28 more
TL;DR: In this article, a computationally designed, two-component nanoparticle immunogens were shown to induce potently neutralizing and broadly protective antibody responses against a wide variety of influenza viruses.
Journal ArticleDOI
Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine
TL;DR: Data indicate that divergent viruses that did not cross-react serologically did not provide complete cross-protection when used in inactivated vaccines against heterologous challenge and may have enhanced disease.
Journal ArticleDOI
Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets
Florian Krammer,Rong Hai,Mark A. Yondola,Gene S. Tan,Victor H. Leyva-Grado,Alex B. Ryder,Matthew S. Miller,John K. Rose,Peter Palese,Adolfo García-Sastre,Randy A. Albrecht +10 more
TL;DR: Both strategies showed efficacy in reducing viral loads after an influenza virus challenge in the ferret model support the development of vaccines stimulating stalk-specific antibody responses.
Journal ArticleDOI
Spread of Antigenically Drifted Influenza A(H3N2) Viruses and Vaccine Effectiveness in the United States During the 2018-2019 Season.
Brendan Flannery,Rebecca Kondor,Jessie R Chung,Manjusha Gaglani,Michael D. Reis,Richard K. Zimmerman,Mary Patricia Nowalk,Michael L. Jackson,Lisa A. Jackson,Arnold S. Monto,Emily T. Martin,Edward A. Belongia,Huong Q. McLean,Sara S Kim,Lenee Blanton,Krista Kniss,Alicia P. Budd,Lynnette Brammer,Thomas J. Stark,John R. Barnes,David E. Wentworth,Alicia M. Fry,Manish M. Patel +22 more
TL;DR: Predominance of A(H3N2) clade 3C.3a viruses during the latter part of the 2018-2019 season was associated with decreased vaccine effectiveness, supporting the A( H3n2) vaccine component update for 2019-2020 northern hemisphere influenza vaccines.
Journal ArticleDOI
The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesis.
Martin G. Ottolini,Jorge C. G. Blanco,Maryna C. Eichelberger,David D. Porter,Lioubov M. Pletneva,Joann Y. Richardson,Gregory A. Prince +6 more
TL;DR: Results indicate that cotton rats will be useful for further studies of influenza pathogenesis and immunity, and a biphasic response was observed for RANTES, IFN-gamma, IL4, IL10 and IL12-p40, with increased mRNA levels early during virus replication followed by a later increase that coincided with pulmonary inflammation.