Animal Models Utilized for the Development of Influenza Virus Vaccines.
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In this article, the authors describe seasonal and novel influenza virus vaccines and highlight important animal models used to develop them, and highlight the importance of animal models in the development of influenza vaccines.About:
This article is published in Vaccine.The article was published on 2021-07-14 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Antigenic drift.read more
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Journal ArticleDOI
Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection
Ajitanuj Rattan,Chantelle L. White,Sean Nelson,Max Eismann,Herbey Oswaldo Padilla-Quirarte,Maryah A. Glover,Thamotharampillai Dileepan,Bindumadhav M. Marathe,Elena A. Govorkova,Richard J. Webby,Katherine A. Richards,Andrea J. Sant +11 more
TL;DR: The C57BL/6 mouse model of intranasal infection with influenza B (B/Brisbane/60/2008) virus is developed and utilized and a series of robustly elicited individual CD4 T cell peptide specificities are identified, enabling more sophisticated analyses of influenza B virus infection.
Journal ArticleDOI
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Bianca Libanori Artiaga,Igor Morozov,Russell Ransburgh,Taeyong Kwon,Velmurugan Balaraman,Sabarish V. Indran,Darling Melany de Carvalho Madrid,Weihong Gu,Jamie Henningson,Wenjun Ma,Jürgen A. Richt,John P. Driver +11 more
TL;DR: In this article , the authors used the swine influenza challenge model to assess whether α-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 LAIV vaccine (TX98ΔNS1) encoding a truncated NS1 protein.
Journal ArticleDOI
Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life
Ria Goswami,Carolina Garrido Pavon,I. Miller,Stella J. Berendam,Caitlin A. Williams,Danielle M. Rosenthal,M. Gross,Caroline T. Phan,Alliyah U. Byrd,Justin Pollara,Sallie R. Permar,Genevieve G. Fouda +11 more
TL;DR: The protective role of maternal antibodies against three categories of viruses: viruses that cause severe maternal disease outcomes with mainly indirect consequences to the fetus, those that are vertically transmitted from mother to their infants, and those that cause elevated disease severity among neonates and infants postnatally are discussed.
Posted ContentDOI
Ultrasound examination for diagnosing pneumopathies in New World primates, focusing on pulmonary consolidation
TL;DR: In this paper , the authors evaluated the contribution of ultrasound examinations of the thoracic region of Callithrix sp in diagnosing pneumopathy and found that the combination of air and soft tissues confirms imaging artifacts that may contribute to differentiation of healthy lung tissue from deteriorated lung tissue.
Book ChapterDOI
Detection and Prevention of Virus Infection.
Yu Wang,Bairong Shen +1 more
TL;DR: In this article , the authors outlined traditional approaches and emerging technologies of virus detection and prevention, and then summarized the latest developments in the bioinformatics methods application in different fields of virus researches, highlighting machine learning and deep learning algorithms to identify factors/categories from complex multidimensional data and uncover novel patterns of virus or disease risk prediction.
References
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Journal ArticleDOI
Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine.
Huilin Ou,Wei Yao,Nanping Wu,Frederick Wang,Tianhao Weng,Chengcong Han,Xiangyun Lu,Dong-Shan Yu,Haibo Wu,Linfang Cheng,Honglin Chen,Hangping Yao,Lanjuan Li +12 more
TL;DR: This study produced a monovalent split influenza A (H7N9) MF59-adjuvanted vaccine that was immunogenic in mice and verified that the virulence and transmissibility of the recombinant H7n9 vaccine seed strain were decreased as compared to wild-type H7N 9 virus, to levels comparable with PR8.
Journal ArticleDOI
The effect of protein-deprivation on the susceptibility to influenza virus infection: a murine model system.
TL;DR: The effect of a 4% albumin diet initiated at weaning on the susceptibility to influenza virus infection was studied in C57Bl mice and the potential risk of epidemic influenza in children suffering from severe forms of protein-energy malnutrition was discussed.
Journal ArticleDOI
Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model.
Wen-Chun Liu,Raffael Nachbagauer,Daniel Stadlbauer,Shirin Strohmeier,Alicia Solórzano,Francesco Berlanda-Scorza,Bruce L Innis,Adolfo García-Sastre,Peter Palese,Florian Krammer,Randy A. Albrecht +10 more
TL;DR: In this article, a chimeric hemagglutinin (cHA)-based universal influenza virus vaccine was developed, which contains a conserved HA stalk domain from a 2009 pandemic H1N1 (pH1N 1) strain combined with globular head domains from avian influenza A viruses.
Journal ArticleDOI
Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice.
Zhe Hu,Yiran Zhang,Zhen Wang,Jingjing Wang,Qi Tong,Mingyang Wang,Honglei Sun,Juan Pu,Changqing Liu,Jinhua Liu,Yipeng Sun +10 more
TL;DR: Different lineages of H9N2 could adapt well in mice and some viruses could gain the ability to replicate systemically and become neurovirulent, so it is essential to pay attention to the mammalian adaptive evolution of the H9n2 virus.
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Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection.
TL;DR: DBA/2J mice represent a suitable mouse model to evaluate virulence and pathogenicity as well as immunization regimes against existing and newly emerging human influenza strains without the need for prior adaptation of the virus to the mouse.