Antiviral immunity in marine molluscs.
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TLDR
Recent developments in molluscan antiviral immunity against viruses belonging to the order Herpesvirales are reviewed, suggesting an interferon-like response and autophagy are involved in the antiviral defence of bivalves to viral infection.Abstract:
Marine molluscs, like all living organisms, are constantly exposed to viruses and have evolved efficient antiviral defences. We review here recent developments in molluscan antiviral immunity against viruses belonging to the order Herpesvirales. Emerging results suggest an interferon-like response and autophagy are involved in the antiviral defence of bivalves to viral infection. Multi-functional plasma proteins from gastropods and bivalves have been identified to have broad-spectrum antiviral activity against mammalian viruses. The antiviral defences present in molluscs can be enhanced by genetic selection, as shown by the presence of oyster strains specifically resistant to ostreid herpesvirus type 1. Whether varying amounts or different isoforms of these antiviral plasma proteins contributes to genetic resistance is worthy of further research. Other evolutionarily conserved antiviral mechanisms, such as RNA interference and apoptosis, still need further characterization.read more
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Book ChapterDOI
Immunity in Molluscs: Recognition and Effector Mechanisms, with a Focus on Bivalvia
Marco Gerdol,Marta Gomez-Chiarri,Maria G. Castillo,Antonio Figueras,Graziano Fiorito,Rebeca Moreira,Beatriz Novoa,Alberto Pallavicini,Giovanna Ponte,Katina Roumbedakis,Paola Venier,Gerardo R. Vasta +11 more
TL;DR: The development of comparative functional studies using natural and selectively bred disease-resistant strains, together with the potential but yet to be fully developed application of gene-editing technologies, should provide exciting insights into the functional relevance of immune gene family expansion and molecular diversification in bivalves.
Journal ArticleDOI
Viruses infecting marine molluscs
TL;DR: Control and management of viral diseases in molluscs mostly involve active surveillance, implementation of effective bio security measures and development of breeding programs, however factors triggering pathogen development and the life cycle and status of the viruses outside their mollusc hosts still need further investigations.
Journal ArticleDOI
Long-lasting antiviral innate immune priming in the Lophotrochozoan Pacific oyster, Crassostrea gigas.
Maxime Lafont,Bruno Petton,Agnès Vergnes,Marianna Pauletto,Amélie Segarra,Benjamin Gourbal,Caroline Montagnani +6 more
TL;DR: This study showed that various nucleic acid injections can prime oysters to trigger an antiviral state ultimately protecting them against a subsequent viral infection, suggesting for the first time the existence of innate immune memory in this invertebrate species.
Journal ArticleDOI
Antiviral Defense and Innate Immune Memory in the Oyster.
Timothy J. Green,Peter Speck +1 more
TL;DR: Experimental evidence indicates that the oyster’s antiviral defense system exhibits a form of innate immune-memory, and this knowledge will motivate the development of practical and cost-effective treatments for improving oyster health in aquaculture.
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Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates.
TL;DR: In invertebrate MAVS-dependent RLR signalling is established for the first time and would be helpful for deciphering the antiviral mechanisms of invertebrates and understanding the development of the vertebrate RLR network.
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TL;DR: The sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy and transcriptomes of development and stress response and the proteome of the shell are reported, showing that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes.
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