Butyrate: A Double-Edged Sword for Health?
TLDR
The present knowledge on the properties of butyrate, especially its potential effects and mechanisms involved in intestinal health and obesity, are summarized.About:
This article is published in Advances in Nutrition.The article was published on 2018-01-01 and is currently open access. It has received 542 citations till now. The article focuses on the topics: Butyrate & Gut–brain axis.read more
Citations
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Branched Chain Amino Acids: Beyond Nutrition Metabolism
TL;DR: Current evidence supports BCAAs and their derivatives as the potential biomarkers of diseases such as insulin resistance, type 2 diabetes mellitus, cancer, and cardiovascular diseases (CVDs), and optimizing dietary BCAA levels should have a positive effect on the parameters associated with health and diseases.
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Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation.
Knud Erik Bach Knudsen,Helle Nygaard Lærke,Mette Skou Hedemann,Tina Skau Nielsen,Anne Krog Ingerslev,Ditte Søvsø Gundelund Nielsen,Peter Kappel Theil,Stig Purup,Stine Hald,Anne Grethe Schioldan,Maria L. Marco,Søren Gregersen,Kjeld Hermansen +12 more
TL;DR: The effect of butyrate seems generally to be more consistent and positive oninflammatory markers related to the gut than on inflammatory markers in the peripheral tissue, and this discrepancy may be explained by differences inbutyrate concentrations in the gut compared with the much lower concentration at more remote sites.
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Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond.
TL;DR: A working definition and review currently known postbiotic compounds, their proposed mechanisms, clinical evidence and potential applications are proposed.
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Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria
TL;DR: In this review, several representative NDCs are introduced, and their chemical components, structures, and physiological functions, including promotion of the proliferation of butyrate-producing bacteria and enhancement ofbutyrate production are discussed.
Journal ArticleDOI
Clostridium species as probiotics: potentials and challenges.
TL;DR: This review summarized the researches involved in benefits and potential risks of Clostridium species to the authors' health, in order to develop Clostridgeium species as novel probiotics for human health and animal production.
References
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Chunaram Choudhary,Chanchal Kumar,Florian Gnad,Michael L. Nielsen,Michael Rehman,Tobias C. Walther,Jesper V. Olsen,Matthias Mann +7 more
TL;DR: A proteomic-scale analysis of protein acetylation suggests that it is an important biological regulatory mechanism and the regulatory scope of lysine acetylations is broad and comparable with that of other major posttranslational modifications.
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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis
Patrick M. Smith,Michael R. Howitt,Nicolai Panikov,Monia Michaud,Carey Ann Gallini,Mohammad Bohlooly-Y,Jonathan N. Glickman,Wendy S. Garrett +7 more
TL;DR: This study determined that short-chain fatty acids, gut microbiota–derived bacterial fermentation products, regulate the size and function of the colonic Treg pool and protect against colitis in a Ffar2-dependent manner in mice, revealing that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health.
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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
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Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more
TL;DR: The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
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