CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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The role of hypoxia and adenosine signaling in vaccine design
TL;DR: In this paper, the authors present a Table of Table of contents of a table.iii Acknowledgements and acknowledgements for the Table of Contents.IV Table 1.1.
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The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy.
TL;DR: It is suggested that checkpoint blockade may improve responses to immunotherapy in elderly hosts with mesothelioma, and warrants further investigation.
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Pyroptosis in spinal cord injury
TL;DR: In this article , the authors reviewed the evidence for pyroptosis in spinal cord injury, and focused on the pyropletosis of different cells and the crosstalk between them.
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Improved metabolism and redox state with a novel preservation solution: implications for donor lungs after cardiac death (DCD).
David Schipper,David Schipper,Anthony V. Louis,Destiny S. Dicken,Kitsie Johnson,Ryszard T. Smolenski,Stephen M. Black,Raymond B. Runyan,John P. Konhilas,Joe G.N. Garcia,Zain Khalpey +10 more
TL;DR: The study suggests suboptimal metabolic preservation in lungs stored in LPD, which may have immediate clinical implications for human organs; however, further investigation is needed to evaluate DCD lung preservation in Somah as a viable option for transplant.
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The evaluation of CD39, CD73, and HIF-1 α expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss.
Forough Parhizkar,Amir Kiani,Sati Nik Darzi,Roza Motavalli,Fatemeh Noori Dolama,Yousef Yousefzadeh,Leili Aghebati-Maleki,Helen Pia,Sedigheh Abdollahi-Fard,Amirhossein Mardi,Shahla Danaii,Javad Ahmadian Heris,Mehdi Yousefi,Mohammad Sadegh Soltani-Zangbar +13 more
TL;DR: In this paper , the authors measured the molecules associated with ATP catabolism and hypoxia besides their related miRNAs in patients with recurrent pregnancy loss and healthy pregnant women with Flow cytometry.
References
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K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
TL;DR: In the 10 years since the previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations, but there have been so many other developments that an update is needed.