CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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Journal ArticleDOI
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression
María Rosa Bono,Dominique Fernández,Felipe Flores-Santibáñez,Mario Rosemblatt,Mario Rosemblatt,Daniela Sauma +5 more
TL;DR: Evidence that supports a role of CD73 and CD39 ectonucleotidases in controlling naive T‐cell homeostasis and memory cell survival through adenosine production is discussed and a novel hypothesis of a possible role of these ecton nucleotidase and autocrine adenosines signaling in controlling T‐ cell differentiation is proposed.
Journal ArticleDOI
Targeting Adenosine Receptor Signaling in Cancer Immunotherapy
Kevin Sek,Christina Mølck,Gregory D. Stewart,Lev Kats,Lev Kats,Phillip K. Darcy,Paul A. Beavis,Paul A. Beavis +7 more
TL;DR: The role ofadenosine and adenosine receptor signaling in tumor and immune cells with a focus on their cell-specific function and their potential as targets in cancer immunotherapy is discussed.
Journal ArticleDOI
The roles of CD73 in cancer.
TL;DR: The multiple roles of CD73 in cancer development, including its clinical significance, its promotive effects on tumor growth, metastasis, and angiogenesis, and its suppressive effects on immune response are summarized.
Journal ArticleDOI
CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis
Xiao-Lu Ma,Minna Shen,Bo Hu,Beili Wang,Wen-Jing Yang,Li-Hua Lv,Hao Wang,Yan Zhou,An-Li Jin,Yun-Fan Sun,Chuan-Yan Zhang,Shuang-Jian Qiu,Baishen Pan,Jian Zhou,Jia Fan,Xin-Rong Yang,Wei Guo +16 more
TL;DR: It is demonstrated that CD73 was crucial for epithelial-mesenchymal transition (EMT), progression and metastasis in HCC and co-targeting CD73 and A2AR strategy may be a promising novel therapeutic strategy for future HCC management.
Journal ArticleDOI
Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations
TL;DR: The role of the adenosine–adenosine receptor system in regulating both the onset and progression of T1DM and T2DM, and the potential of pharmacological manipulation of theadenosinergic system as an approach to manage T1 DM, T2 DM and their associated complications are discussed.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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How regulatory T cells work.
TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
TL;DR: In the 10 years since the previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations, but there have been so many other developments that an update is needed.