CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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Journal ArticleDOI
Inhibition of ecto-ATPase activities impairs HIV-1 infection of macrophages
Julieta Schachter,Kelly Valcárcel Delgado,Victor Barreto-de-Souza,Dumith Chequer Bou-Habib,Pedro M. Persechini,José Roberto Meyer-Fernandes +5 more
TL;DR: It is found that the kinetic properties of HIV-1 and macrophage ecto-ATPases are similar, suggesting that the enzyme is the same, and elevated extracellular concentrations of ATP inhibit HIV- 1 production by infected macrophages.
Journal ArticleDOI
P2X4 receptors, immunity, and sepsis.
TL;DR: The present review provides an outline of the role played by P2X4 receptors in the modulation of the host's response to sepsis and the promise that targeting this receptor holds in the treatment of septicaemia.
Journal ArticleDOI
Ectonucleotidase-Mediated Suppression of Lupus Autoimmunity and Vascular Dysfunction.
Jason S. Knight,Levi F. Mazza,Srilakshmi Yalavarthi,Gautam Sule,Ramadan A. Ali,Jeffrey B. Hodgin,Yogendra Kanthi,David J. Pinsky +7 more
TL;DR: These data are the first to link ectonucleotidases with lupus autoimmunity and vascular disease and new therapeutic strategies may harness purinergic nucleotide dissipation or signaling to limit the damage inflicted upon organs and blood vessels by l upus.
Journal ArticleDOI
Extracellular Vesicles Secreted by Mesenchymal Stromal Cells Exert Opposite Effects to Their Cells of Origin in Murine Sodium Dextran Sulfate-Induced Colitis
Anna Maria Tolomeo,Ignazio Castagliuolo,Martina Piccoli,Michele Grassi,Fabio Magarotto,Giada De Lazzari,Ricardo Malvicini,Federico Caicci,Chiara Franzin,Melania Scarpa,Veronica Macchi,Raffaele De Caro,Imerio Angriman,Antonella Viola,Andrea Porzionato,Michela Pozzobon,Maurizio Muraca +16 more
TL;DR: In this paper, the effects of mesenchymal stromal cells (MSC) and of their secreted extracellular vesicles (EVs) in mice with experimental colitis were compared.
Journal ArticleDOI
Extracellular release of ATP promotes systemic inflammation during acute pancreatitis
Ajay Dixit,Hassam Cheema,John George,Srikanth Iyer,Vikas Dudeja,Rajinder Dawra,Ashok K. Saluja +6 more
TL;DR: The role of eATP and P2 receptors in pancreas and lungs were significantly elevated in the experimental models of AP andModulating purinergic signaling during AP can be an important therapeutic strategy in controlling systemic inflammation and thus, SIRS during AP.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
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