CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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Journal ArticleDOI
Consensus guidelines for the detection of immunogenic cell death
Oliver Kepp,Laura Senovilla,Ilio Vitale,Erika Vacchelli,Sandy Adjemian,Patrizia Agostinis,Lionel Apetoh,Fernando Aranda,Vincenzo Barnaba,Norma Bloy,Laura Bracci,Karine Breckpot,David Brough,Aitziber Buqué,Maria G. Castro,Mara Cirone,María Isabel Colombo,Isabelle Cremer,Sandra Demaria,Luciana Dini,Aristides G. Eliopoulos,Alberto Faggioni,Silvia C. Formenti,Jitka Fucikova,Lucia Gabriele,Udo S. Gaipl,Jérôme Galon,Abhishek D. Garg,François Ghiringhelli,Nathalia A. Giese,Zong Sheng Guo,Akseli Hemminki,Martin Herrmann,James W. Hodge,Stefan Holdenrieder,Jamie Honeychurch,Hong-Min Hu,Xing Huang,Timothy M Illidge,Koji Kono,Mladen Korbelik,Dmitri V. Krysko,Sherene Loi,Pedro R. Lowenstein,Enrico Lugli,Yuting Ma,Frank Madeo,Angelo A. Manfredi,Isabelle Martins,Domenico Mavilio,Laurie Menger,Nicolò Merendino,Michael Michaud,Grégoire Mignot,Karen L. Mossman,Gabriele Multhoff,Rudolf Oehler,Fabio Palombo,Theocharis Panaretakis,Jonathan Pol,Enrico Proietti,Jean-Ehrland Ricci,Chiara Riganti,Patrizia Rovere-Querini,Anna Rubartelli,Antonella Sistigu,Mark J. Smyth,Juergen Sonnemann,Radek Spisek,John Stagg,Abdul Qader Sukkurwala,Eric Tartour,Andrew Thorburn,Stephen H. Thorne,Peter Vandenabeele,Francesca Velotti,Samuel T Workenhe,Haining Yang,Wei-Xing Zong,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +81 more
TL;DR: Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed.
Journal ArticleDOI
Immunity, inflammation and cancer: a leading role for adenosine
TL;DR: The role of adenosine and its receptors in regulating the complex interplay among immune, inflammatory, endothelial and cancer cells during the course of neoplastic disease is critically discussed.
Journal ArticleDOI
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets.
TL;DR: Insight into potential clinical application of adenosinergic and other purinergic‐targeting therapies and forecast how these might develop in combination with other anti‐cancer modalities are provided.
Journal ArticleDOI
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
Thomas Duhen,Rebekka Duhen,Ryan Montler,Jake Moses,Tarsem Moudgil,Noel F C C de Miranda,Cheri P. Goodall,Tiffany C. Blair,Bernard A. Fox,Jason E. McDermott,Shu Ching Chang,Gary L. Grunkemeier,Rom Leidner,R.B. Bell,Andrew D. Weinberg +14 more
TL;DR: The authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit characteristics of exhausted or tissue-resident memory T cells, which may lead to future adoptive T-cell cancer therapies.
Journal ArticleDOI
Targeting immunosuppressive adenosine in cancer
TL;DR: The complex interplay ofadenosine and adenosine receptors in the development of primary tumours and metastases is described and the merits of targeting one or more components that compose the adenosinergic pathway are discussed.
References
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Journal ArticleDOI
CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
Xiaofeng Sun,Yan Wu,Wenda Gao,Keiichi Enjyoji,Eva Csizmadia,Christa E. Müller,Takashi Murakami,Simon C. Robson +7 more
TL;DR: It is demonstrated that hepatic growth of melanoma metastatic tumors was strongly inhibited in mice with Cd39 null vasculature or in wt mice with circulating Cd40 null bone marrow-derived cells, and inhibition of CD39 activity by polyoxometalate-1 significantly inhibited tumor growth.
Journal ArticleDOI
Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma.
Bin Zhang,Zhijun Wang,Liangliang Wu,Meng Zhang,Wei Li,Jian-Hua Ding,Jun Zhu,Huafeng Wei,Ke Zhao +8 more
TL;DR: Results demonstrate that peripheral blood from colorectal cancer patients contains markedly increased percentage and absolute number of Lin−/lowHLA-DR−CD11b+CD33+ MDSCs compared with healthy individuals, and this increase is closely correlated with clinical cancer stage and tumor metastasis but not primary tumor size and serum concentrations of cancer biomarker.
Journal ArticleDOI
Neutrophil-derived 5′-Adenosine Monophosphate Promotes Endothelial Barrier Function via CD73-mediated Conversion to Adenosine and Endothelial A2B Receptor Activation
TL;DR: Activated PMN release soluble mediators, such as 5′-AMP and adenosine, that promote endothelial barrier function and could serve as a basic mechanism of endothelial resealing during PMN transendothelial migration during inflammation.
Journal ArticleDOI
NTPDase and 5'-nucleotidase activities in physiological and disease conditions: new perspectives for human health.
TL;DR: Changes in ATP, ADP and AMP hydrolysis induced by inborn errors of metabolism, seizures and epilepsy are discussed in order to highlight the importance of these enzymes in the control of neuronal activity in pathological conditions.
Book ChapterDOI
Ectonucleotidases as Regulators of Purinergic Signaling in Thrombosis, Inflammation, and Immunity
Silvia Deaglio,Simon C. Robson +1 more
TL;DR: The CD38/CD157 family of extracellular NADases degrades NAD(+) and generates Ca(2+)-active metabolites, including cyclic ADP ribose and Adp ribose as mentioned in this paper.