CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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Journal ArticleDOI
Regulation of immune responses by ATP-hydrolyzing ecto-enzymes
TL;DR: ATP-hydrolyzing ecto-enzymes modulate the immune response through ATP hydrolysis through inhibition of E-NTPD and E-NPP protein families.
Journal ArticleDOI
Immunosuppression impaired the immunogenicity of inactivated SARS-CoV-2 vaccine in non-dialysis kidney disease patients
Yi Zhang,X. D. Liu,M. Lin,Jindong Zan,Y Hu,X. L. Wang,W. Wu,T Zhou,H. Zhang,J. L. Lv,L. Yang,Z. Zhang +11 more
TL;DR: Wu et al. as discussed by the authors conducted a pilot, prospective study to survey the safety and humoral response to inactivated SARS-CoV-2 vaccine in patients with chronic kidney disease, on dialysis or after kidney transplant.
Journal ArticleDOI
SARS-CoV-2 Vaccine-Induced T-Cell Response after Three Doses in People Living with HIV on Antiretroviral Therapy Compared to Seronegative Controls (CTN 328 COVAXHIV Study)
Yulia Alexandrova,Alexis Yero,Ralph-Sydney Mboumba Bouassa,Eve Comeau,Suzanne Samarani,Zabrina L. Brumme,Mark Hull,Angela M. Crawley,Marc-André Langlois,Jonathan B. Angel,Curtis Cooper,Judy Needham,Terry C.K. Lee,Joel Singer,Aslam H. Anis,Cecilia T. Costiniuk,Mohammad-Ali Jenabian +16 more
TL;DR: In this article , the authors assessed T-cell immunogenicity following three SARS-CoV-2 vaccine doses in people living with HIV versus uninfected controls, and found that two doses of SARS CoV2 vaccine induced a robust Tcell immune response in PLWH, which was maintained after the 3rd dose.
Journal ArticleDOI
Resolution Potential of Necrotic Cell Death Pathways
TL;DR: In this paper , the relationship between necrotic cell death and resolution was summarized and the current available data regarding the involvement of certain forms of regulated necrosis cell death in necroresolution was presented.
Journal ArticleDOI
Downregulation of CD73 on CD4+ T cells from patients with chronic Chikungunya infection.
Pedro Henrique de Sousa Palmeira,Bruna Macêdo Gois,Isabel Cristina Guerra-Gomes,Rephany Fonseca Peixoto,Cínthia Nóbrega de Sousa Dias,Josélio Maria Galvão de Araújo,Ian P.G. Amaral,Tatjana Souza Lima Keesen +7 more
TL;DR: The ectoenzymes CD39 and CD73, also expressed by CD4 T lymphocytes, are involved in the hydrolysis of pro-inflammatory extracellular ATP and generation of immunosuppressive adenosine and seem to be modulated in some arthritogenic pathologies as mentioned in this paper .
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
Journal ArticleDOI
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
Journal ArticleDOI
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
Journal ArticleDOI
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
TL;DR: In the 10 years since the previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations, but there have been so many other developments that an update is needed.