CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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Journal ArticleDOI
Construction of Antithrombotic Tissue-Engineered Blood Vessel via Reduced Graphene Oxide Based Dual-Enzyme Biomimetic Cascade
Da Huo,Ge Liu,Yanzhao Li,Yuxin Wang,Ge Guan,Mingcan Yang,Keyu Wei,Jingyuan Yang,Lingqin Zeng,Gang Li,Wen Zeng,Chuhong Zhu +11 more
TL;DR: Inspired by the phenomenon that endothelial cells continuously generate endogenous antiplatelet substances via enzymatic reactions, a reduced graphene oxide (RGO) based dual-enzyme biomimetic cascade is designed to successively convert ADP into adenosine monophosphate (AMP) and AMP intoadenosine.
Journal ArticleDOI
Microvesicles expressing adenosinergic ectoenzymes and their potential role in modulating bone marrow infiltration by neuroblastoma cells.
TL;DR: Etononucleotidases are present and functional on NB cells, as well as in NB-infiltrated BM and in MV derived from BM, and it is reasonable that MV are involved in BM infiltration by NB cells.
Journal ArticleDOI
Phenotypical analysis of ectoenzymes CD39/CD73 and adenosine receptor 2A in CD4+CD25highFoxp3+ regulatory T-cells in psoriasis
Ling Han,Hideaki Sugiyama,Qi Zhang,Kexiang Yan,Xu Fang,Thomas S. McCormick,Kevin D. Cooper,Qiong Huang +7 more
TL;DR: The frequencies and phenotypes of CD39/CD73‐expressing Tregs and related receptor adenosine receptor 2A (A2AR) in peripheral blood of patients with different types of psoriasis are examined.
Journal ArticleDOI
Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071.
Matthias Zebisch,Matthias Zebisch,Younis Baqi,Petra Schäfer,Christa E. Müller,Norbert Sträter +5 more
TL;DR: Structural insight into NTPDase inhibition is presented and the observation of the putative membrane interaction loop (MIL) in two different conformations related by a 10° rotation identifies the MIL as a dynamic section of NTPDases that is potentially involved in regulation of catalysis.
Journal ArticleDOI
A Randomized, Placebo-Controlled, Pilot Clinical Trial of Dipyridamole to Decrease Human Immunodeficiency Virus-Associated Chronic Inflammation.
Bernard J.C. Macatangay,Edwin K. Jackson,Kaleab Z. Abebe,Diane M. Comer,Joshua C. Cyktor,Cynthia Klamar-Blain,Luann Borowski,Delbert G. Gillespie,John W. Mellors,Charles R. Rinaldo,Sharon A. Riddler +10 more
TL;DR: Dipyridamole increased extracellular adenosine levels and decreased T cell activation significantly among persons with HIV-1 infection on virally-suppressive therapy.
References
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
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Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
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