CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine
Kanchan Singh,Erika Y. Faraoni,Yulin Dai,Vidhi Chandra,Emily A. Vucic,Tingting Mills,Melissa Pruski,Trent Clark,George Van Buren,Nirav Thosani,John S. Bynon,Curtis J. Wray,Dafna Bar-Sagi,Kyle L. Poulsen,Lana A. Vornik,Michelle I. Savage,Shizuko Sei,Altaf Mohammed,Zhongming Zhao,Holger K. Eltzschig,Powel H. Brown,Florencia McAllister,Jennifer Bailey Lundberg +22 more
TL;DR: Vardef et al. as mentioned in this paper investigated the initial triggers of immunosuppression during the process of pancreatic tumorigenesis and established tumors, and found that ductal activation of oncogenic mutant Kras results in loss of PTEN and elevated AKT signaling which ultimately releases CD73 suppression.
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Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung
Juho Jalkanen,Ville Pettilä,Matti K Karvonen,Teppo Huttunen,J. Mandelin,Markku Jalkanen,Markus Malmberg,Kati Elima,Geoff Bellingan,Maija Hollmén,V. Marco Ranieri,Sirpa Jalkanen +11 more
TL;DR: This work finds that hydrocortisone reduces the production, and prevents the nuclear translocation of IRF9, that is required for IFN beta-dependent signaling of multiple IFN-induced genes, and provides the mechanistic basis for the harmful association of glucocorticoids in IFN Beta treated patients in the INTEREST-trial.
Identification and characterization of tissue-resident memory T cells in humans
TL;DR: Identification and characterization of tissue-resident memory T cells in humans and the role of TNFs in wound healing and wound healing is studied.
Journal ArticleDOI
Decreased CD73+ Double-Negative T Cells and Elevated Level of Soluble CD73 Correlated With and Predicted Poor Immune Reconstitution in HIV-Infected Patients After Antiretroviral Therapy
Xinyue Wang,Leidan Zhang,Juan Du,Yuqing Wei,Di Wang,Chuan Song,Danying Chen,Bei Li,Meiqi Jiang,Mengyuan Zhang,Hongxin Zhao,Yaxian Kong +11 more
TL;DR: A significant downregulation of CD73 expression on DNT cells in treatment-naïve PLWH (TNs) compared to healthy controls, accompanied with increased concentration of sCD73 in plasma is found, providing evidences for sCD 73 as a potential biomarker of predicting immune recovery.
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Inflammatory profile in cervical cancer: influence of purinergic signaling and possible therapeutic targets
Maria Luiza Mukai Franciosi,Thiago Inácio Teixeira do Carmo,Daniela Zanini,Andréia Machado Cardoso +3 more
TL;DR: The association between the immune system and the purinergic system, already known in other types of disease, also presents possibilities for a better understanding of biomolecular processes and therapeutic possibilities in the context of cervical cancer.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
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TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
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